rhythm generation through period concatenation in rat somatosensory cortex节奏一代通过连接在鼠躯体感觉皮质.pdfVIP

Rhythm Generation through Period Concatenation in Rat Somatosensory Cortex 1,2 3 3 4 3 Mark A. Kramer *, Anita K. Roopun , Lucy M. Carracedo , Roger D. Traub , Miles A. Whittington , Nancy J. Kopell1,2 1 Department of Mathematics and Statistics, Boston University, Boston, Massachusetts, United States of America, 2 Center for BioDynamics, Boston University, Boston, Massachusetts, United States of America, 3 Institute of Neuroscience, Newcastle University, Newcastle, United Kingdom, 4 Department of Physiology and Pharmacology, SUNY Health Sciences Center, Brooklyn, New York, United States of America Abstract Rhythmic voltage oscillations resulting from the summed activity of neuronal populations occur in many nervous systems. Contemporary observations suggest that coexistent oscillations interact and, in time, may switch in dominance. We recently reported an example of these interactions recorded from in vitro preparations of rat somatosensory cortex. We found that following an initial interval of coexistent gamma (,25 ms period) and beta2 (,40 ms period) rhythms in the superficial and deep cortical layers, respectively, a transition to a synchronous beta1 (,65 ms period) rhythm in all cortical layers occurred. We proposed that the switch to beta1 activity resulted from the novel mechanism of period concatenation of the faster rhythms: gamma period (25 ms)+beta2 period (40 ms) = beta1 period (65 ms). In this article, we investigate in greater detail the fundamental mechanisms of the beta1 rhythm. To do so we describe additional in vitro experiments that constrain a biologically realistic, yet simplified, computational model of the activity. We use the model to suggest that the dynamic building blocks (or motifs) of the gamma and beta2