short-term memory trace in rapidly adapting synapses of inferior temporal cortex短期记忆痕迹下颞叶皮层的迅速适应突触.pdfVIP

Short-Term Memory Trace in Rapidly Adapting Synapses of Inferior Temporal Cortex 1,2,3 1 4 5 1 Yasuko Sugase-Miyamoto , Zheng Liu , Matthew C. Wiener , Lance M. Optican , Barry J. Richmond * 1 Laboratory of Neuropsychology, National Institute of Mental Health, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland, United States of America, 2 JSPS Overseas Research Fellow, Japan Society for the Promotion of Science, Tokyo, Japan, 3 Neuroscience Research Institute, National Institute of Advanced Industrial Science and Technology, Tsukuba, Japan, 4 RY84-202, Applied Computer Science and Mathematics Department, Merck Research Laboratories, Rahway, New Jersey, United States of America, 5 Laboratory of Sensorimotor Research, Intramural Research Program, National Eye Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland, United States of America Abstract Visual short-term memory tasks depend upon both the inferior temporal cortex (ITC) and the prefrontal cortex (PFC). Activity in some neurons persists after the first (sample) stimulus is shown. This delay-period activity has been proposed as an important mechanism for working memory. In ITC neurons, intervening (nonmatching) stimuli wipe out the delay-period activity; hence, the role of ITC in memory must depend upon a different mechanism. Here, we look for a possible mechanism by contrasting memory effects in two architectonically different parts of ITC: area TE and the perirhinal cortex. We found that a large proportion (80%) of stimulus-selective neurons in area TE of macaque ITCs exhibit a memory effect during the stimulus interval. During