should burden of disease estimates include cannabis use as a risk factor for psychosis疾病负担估计应该包括大麻使用作为精神病的风险因素.pdfVIP

Research in Translation Should Burden of Disease Estimates Include Cannabis Use as a Risk Factor for Psychosis? 1 2 3 4,5 1 Louisa Degenhardt *, Wayne D. Hall , Michael Lynskey , John McGrath , Jennifer McLaren , Bianca Calabria1, Harvey Whiteford2,5, Theo Vos2 1 National Drug and Alcohol Research Centre, University of New South Wales, Sydney, Australia, 2 School of Population Health, University of Queensland, Herston, Australia, 3 Department of Psychiatry, Washington University School of Medicine, St. Louis, Missouri, United States, 4 Queensland Brain Institute, University of Queensland, St. Lucia, Australia, 5 Queensland Centre for Mental Health Research, University of Queensland, St. Lucia, Australia Introduction Summary Evidence has accumulated suggesting that regular cannabis use is associated with N Comparative risk assessments estimate the proportion of a disease that can be psychotic symptoms and disorders in the attributed to a particular risk exposure and are important guides for health general population [1,2] and elevated planning. among incident cases of psychosis [3,4]. N In observational studies, there has been consistent evidence that cannabis use In this paper, we present the arguments for, is associated with an increased risk of schizophrenia and more generally, and implications of, considering cannabis psychosis. use as a risk factor for psychosis in the 2005 N There is debate about whether such observational evidence is sufficient to infer Global Burden of Disease (GBD) project.