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Open access, freely available online Research Digest Synopses of Research Articles A New Way to Look at thiol modifi cations in proteins subjected many metabolic changes that occur in Oxidative Stress to varying redox conditions in a living oxidatively stressed cells. organism, the bacteria Escherichia coli. Leichert and Jakob’s technique should DOI: 10.1371/journal.pbio.0020374 This technique is capable of providing be applicable to many different cell Chemical reactions lie at the heart a global snapshot of the redox state of types and organisms and can be used protein cysteines during normal and to investigate the in vivo thiol status of of many biological processes, from oxidative stress conditions in the cell. cellular proteins exposed to virtually any photosynthesis and respiration to cell To detect proteins that have the physiological or pathological condition signaling and drug metabolism. Thanks ability to undergo stress-induced thiol that is accompanied by oxidative stress. to an atmosphere rich in oxygen, many modifi cations, Leichert and Jakob The next step will be to investigate just organisms use oxygen to carry out these differentially labeled the thiol groups of how thiol modifi cations mediate the life processes. But oxygen metabolism thi