原创力文档shp-2 promotes the maturation of oligodendrocyte precursor cells through akt and erk12 signaling in vitroshp-2促进成熟的少突细胞前体细胞通过一种蛋白激酶和体外erk12信号.pdfVIP
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shp-2 promotes the maturation of oligodendrocyte precursor cells through akt and erk12 signaling in vitroshp-2促进成熟的少突细胞前体细胞通过一种蛋白激酶和体外erk12信号
SHP-2 Promotes the Maturation of Oligodendrocyte
Precursor Cells Through Akt and ERK1/2 Signaling In
Vitro
Xiujie Liu., Yuanyuan Li., Yong Zhang, Yan Lu, Wei Guo, Peng Liu, Jiazhen Zhou, Zhenghua Xiang,
Cheng He*
Key Laboratory of Molecular Neurobiology, Institute of Neuroscience, Ministry of Education, Neuroscience Research Centre of Changzheng Hospital, Second Military
Medical University, Shanghai, China
Abstract
Background: Oligodendrocyte precursor cells (OPCs) differentiate into oligodendrocytes (OLs), which are responsible for
myelination. Myelin is essential for saltatory nerve conduction in the vertebrate nervous system. However, the molecular
mechanisms of maturation and myelination by oligodendrocytes remain elusive.
Methods and Findings: In the present study, we showed that maturation of oligodendrocytes was attenuated by sodium
orthovanadate (a comprehensive inhibitor of tyrosine phosphatases) and PTPi IV (a specific inhibitor of SHP-2). It is also
found that SHP-2 was persistently expressed during maturation process of OPCs. Down-regulation of endogenous SHP-2 led
to impairment of oligodendrocytes maturation and this effect was triiodo-L-thyronine (T3) dependent. Furthermore, over-
expression of SHP-2 was shown to promote maturation of oligodendrocytes. Finally, it has been identified that SHP-2 was
involved in activation of Akt and extracellular-regulated kinases 1 and 2 (ERK1/2) induced by T3 in oligodendrocytes.
Conclusions: SHP-2 promotes oligodendrocytes maturation via Akt and ERK1/2 signaling in vitro.
Citation: Liu X, Li Y, Zhang Y, Lu Y, Guo W, et al. (2011) SHP-2 Promotes the Maturation of Oligodendrocyte Precursor Cells Through Akt and ERK1/2 Signaling In
Vitro. PLoS ONE 6(6): e21058. doi:10.1371/journal.pone.0021058
Editor: Lin Mei, Medical College of Georgia, United States of America
Received October 20, 2010; Accepted May
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