原创力文档shotgun sequencing analysis of trypanosoma cruzi i sylvio x101 and comparison with t. cruzi vi cl brener巴西政治监督网站巴西政治咨询团体评价鸟枪测序分析鲁兹锥体我x101经克氏锥虫和比较vi cl布雷纳指出.pdfVIP
- 1、原创力文档（book118）网站文档一经付费（服务费），不意味着购买了该文档的版权，仅供个人/单位学习、研究之用，不得用于商业用途，未经授权，严禁复制、发行、汇编、翻译或者网络传播等，侵权必究。。
- 2、本站所有内容均由合作方或网友上传，本站不对文档的完整性、权威性及其观点立场正确性做任何保证或承诺！文档内容仅供研究参考，付费前请自行鉴别。如您付费，意味着您自己接受本站规则且自行承担风险，本站不退款、不进行额外附加服务；查看《如何避免下载的几个坑》。如果您已付费下载过本站文档，您可以点击 这里二次下载。
- 3、如文档侵犯商业秘密、侵犯著作权、侵犯人身权等，请点击“版权申诉”（推荐），也可以打举报电话：400-050-0827(电话支持时间：9:00-18:30)。
- 4、该文档为VIP文档，如果想要下载，成为VIP会员后，下载免费。
- 5、成为VIP后，下载本文档将扣除1次下载权益。下载后，不支持退款、换文档。如有疑问请联系我们。
- 6、成为VIP后，您将拥有八大权益，权益包括：VIP文档下载权益、阅读免打扰、文档格式转换、高级专利检索、专属身份标志、高级客服、多端互通、版权登记。
- 7、VIP文档为合作方或网友上传，每下载1次， 网站将根据用户上传文档的质量评分、类型等，对文档贡献者给予高额补贴、流量扶持。如果你也想贡献VIP文档。上传文档
查看更多
shotgun sequencing analysis of trypanosoma cruzi i sylvio x101 and comparison with t. cruzi vi cl brener巴西政治监督网站巴西政治咨询团体评价鸟枪测序分析鲁兹锥体我x101经克氏锥虫和比较vi cl布雷纳指出
Shotgun Sequencing Analysis of Trypanosoma cruzi I
Sylvio X10/1 and Comparison with T. cruzi VI CL Brener
´ 1 1 1 2 2
Oscar Franzen *, Stephen Ochaya , Ellen Sherwood , Michael D. Lewis , Martin S. Llewellyn , Michael A.
2 ¨ 1
Miles , Bjorn Andersson
1 Science for Life Laboratory, Department of Cell and Molecular Biology, Karolinska Institutet, Stockholm, Sweden, 2 Department of Pathogen Molecular Biology, Faculty
of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, United Kingdom
Abstract
Trypanosoma cruzi is the causative agent of Chagas disease, which affects more than 9 million people in Latin America. We
have generated a draft genome sequence of the TcI strain Sylvio X10/1 and compared it to the TcVI reference strain CL
Brener to identify lineage-specific features. We found virtually no differences in the core gene content of CL Brener and
Sylvio X10/1 by presence/absence analysis, but 6 open reading frames from CL Brener were missing in Sylvio X10/1. Several
multicopy gene families, including DGF, mucin, MASP and GP63 were found to contain substantially fewer genes in Sylvio
X10/1, based on sequence read estimations. 1,861 small insertion-deletion events and 77,349 nucleotide differences, 23% of
which were non-synonymous and associated with radical amino acid changes, further distinguish these two genomes.
There were 336 genes indicated as under positive selection, 145 unique to T. cruzi in comparison to T. brucei and Leishmania.
This study provides a framework for further comparative analyses of two major T. cruzi lineages and also highlights the need
for sequencing more strains to understand fully the genomic composition of this parasite.
您可能关注的文档
- semantic similarity for automatic classification of chemical compounds语义相似度进行自动分类的化合物.pdf
- semantic similarity in biomedical ontologies语义相似度的生物医学本体.pdf
- semantic knowledge influences prewired hedonic responses to odors语义知识影响预配的享乐对气味的反应.pdf
- semaphorin 3a suppresses tumor growth and metastasis in mice melanoma model3 semaphorin抑制小鼠黑色素瘤模型中肿瘤的生长和转移.pdf
- semaphorin-7a is an erythrocyte receptor for p. falciparum merozoite-specific trap homolog, mtrapsemaphorin-7a是恶性疟原虫的红细胞受体merozoite-specific陷阱同族体,mtrap.pdf
- semaphorin-3d and semaphorin-3e inhibit the development of tumors from glioblastoma cells implanted in the cortex of the brainsemaphorin-3d semaphorin-3e抑制肿瘤的发展和胶质母细胞瘤细胞植入大脑皮层.pdf
- sema3a, a gene involved in axonal pathfinding, is mutated in patients with kallmann syndrome基因参与轴突寻路,sema3a突变kallmann综合症患者.pdf
- semi-markov graph dynamics位图动态.pdf
- semi mature blood dendritic cells exist in patients with ductal pancreatic adenocarcinoma owing to inflammatory factors released from the tumor半成熟的血树突状细胞存在于导管胰腺腺癌患者由于炎性因子释放肿瘤.pdf
- senescence is more important in the natural lives of long- than short-lived mammals衰老是自然的生命长,更重要的是比短暂的哺乳动物.pdf
- should i get screened for sleeping sickness a qualitative study in kasai province, democratic republic of congo我应该得到筛查昏睡病定性研究在开赛的一个省,刚果民主共和国.pdf
- should the arteriovenous fistula be created before starting dialysis a decision analytic approach开始透析前动静脉瘘应该创建了一个决策分析方法.pdf
- short lag times for invasive tropical plants evidence from experimental plantings in hawai'i短的延迟时间入侵热带植物来自夏威夷实验种植的证据.pdf
- shp2 knockdown and noonanleopard mutant shp2–induced gastrulation defectsshp2击倒和noonanleopard突变shp2-induced原肠胚形成的缺陷.pdf
- short-term environmental enrichment enhances adult neurogenesis, vascular network and dendritic complexity in the hippocampus of type 1 diabetic mice短期环境富集提高成年神经发生,血管网络和树突的复杂性在1型糖尿病小鼠的海马.pdf
- shrimp accurate mapping of short color-space reads虾准确的短的彩色空间映射读取.pdf
- should burden of disease estimates include cannabis use as a risk factor for psychosis疾病负担估计应该包括大麻使用作为精神病的风险因素.pdf
- shrimp alpha-2-macroglobulin prevents the bacterial escape by inhibiting fibrinolysis of blood clots虾alpha-2-macroglobulin阻止了细菌逃避通过抑制纤维蛋白溶解血凝块.pdf
- shp-2 promotes the maturation of oligodendrocyte precursor cells through akt and erk12 signaling in vitroshp-2促进成熟的少突细胞前体细胞通过一种蛋白激酶和体外erk12信号.pdf
- shotgun lipidomics identifies a paired rule for the presence of isomeric ether phospholipid molecular species猎枪lipidomics识别配对规则的存在异构醚磷脂分子的物种.pdf
文档评论（0）