short-term environmental enrichment enhances adult neurogenesis, vascular network and dendritic complexity in the hippocampus of type 1 diabetic mice短期环境富集提高成年神经发生,血管网络和树突的复杂性在1型糖尿病小鼠的海马.pdfVIP

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short-term environmental enrichment enhances adult neurogenesis, vascular network and dendritic complexity in the hippocampus of type 1 diabetic mice短期环境富集提高成年神经发生,血管网络和树突的复杂性在1型糖尿病小鼠的海马.pdf

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short-term environmental enrichment enhances adult neurogenesis, vascular network and dendritic complexity in the hippocampus of type 1 diabetic mice短期环境富集提高成年神经发生,血管网络和树突的复杂性在1型糖尿病小鼠的海马

Short-Term Environmental Enrichment Enhances Adult Neurogenesis, Vascular Network and Dendritic Complexity in the Hippocampus of Type 1 Diabetic Mice 1 1 1,2 1,2 Juan Beauquis , Paulina Roig , Alejandro F. De Nicola , Flavia Saravia * 1 Institute of Biology and Experimental Medicine, National Research Council (CONICET), Buenos Aires, Argentina, 2 Department of Biochemistry, Faculty of Medicine, University of Buenos Aires, Buenos Aires, Argentina Abstract Background: Several brain disturbances have been described in association to type 1 diabetes in humans. In animal models, hippocampal pathological changes were reported together with cognitive deficits. The exposure to a variety of environmental stimuli during a certain period of time is able to prevent brain alterations and to improve learning and memory in conditions like stress, aging and neurodegenerative processes. Methodology/Principal Findings: We explored the modulation of hippocampal alterations in streptozotocin-induced type 1 diabetic mice by environmental enrichment. In diabetic mice housed in standard conditions we found a reduction of adult neurogenesis in the dentate gyrus, decreased dendritic complexity in CA1 neurons and a smaller vascular fractional area in the dentate gyrus, compared with control animals in the same housing condition. A short exposure -10 days- to an enriched environment was able to enhance proliferation, survival and dendritic arborization of newborn neurons, to recover dendritic tree length and spine density of pyramidal CA1 neurons and to increase the vascular network of the dentate gyrus in diabetic animals. Conclusions/Significance: The environm