原创力文档silencing of glutathione peroxidase 3 through dna hypermethylation is associated with lymph node metastasis in gastric carcinomas沉默的谷胱甘肽过氧化物酶3通过dna甲基化与胃癌癌淋巴结转移有关.pdfVIP
- 1、原创力文档（book118）网站文档一经付费（服务费），不意味着购买了该文档的版权，仅供个人/单位学习、研究之用，不得用于商业用途，未经授权，严禁复制、发行、汇编、翻译或者网络传播等，侵权必究。。
- 2、本站所有内容均由合作方或网友上传，本站不对文档的完整性、权威性及其观点立场正确性做任何保证或承诺！文档内容仅供研究参考，付费前请自行鉴别。如您付费，意味着您自己接受本站规则且自行承担风险，本站不退款、不进行额外附加服务；查看《如何避免下载的几个坑》。如果您已付费下载过本站文档，您可以点击 这里二次下载。
- 3、如文档侵犯商业秘密、侵犯著作权、侵犯人身权等，请点击“版权申诉”（推荐），也可以打举报电话：400-050-0827(电话支持时间：9:00-18:30)。
- 4、该文档为VIP文档，如果想要下载，成为VIP会员后，下载免费。
- 5、成为VIP后，下载本文档将扣除1次下载权益。下载后，不支持退款、换文档。如有疑问请联系我们。
- 6、成为VIP后，您将拥有八大权益，权益包括：VIP文档下载权益、阅读免打扰、文档格式转换、高级专利检索、专属身份标志、高级客服、多端互通、版权登记。
- 7、VIP文档为合作方或网友上传，每下载1次， 网站将根据用户上传文档的质量评分、类型等，对文档贡献者给予高额补贴、流量扶持。如果你也想贡献VIP文档。上传文档
查看更多
silencing of glutathione peroxidase 3 through dna hypermethylation is associated with lymph node metastasis in gastric carcinomas沉默的谷胱甘肽过氧化物酶3通过dna甲基化与胃癌癌淋巴结转移有关
Silencing of Glutathione Peroxidase 3 through DNA
Hypermethylation Is Associated with Lymph Node
Metastasis in Gastric Carcinomas
1 1 2 1,5 5,6 1,3,4
Dun-Fa Peng , Tian-Ling Hu , Barbara G. Schneider , Zheng Chen , Ze-Kuan Xu , Wael El-Rifai *
1 Department of Surgery, Vanderbilt University Medical Center, Nashville, Tennessee, United States of America, 2 Department of Medicine, Vanderbilt University Medical
Center, Nashville, Tennessee, United States of America, 3 Department of Cancer Biology, Vanderbilt University Medical Center, Nashville, Tennessee, United States of
America, 4 Department of Veterans Affairs Tennessee Valley Healthcare System, Nashville, Tennessee, United States of America, 5 Department of General Surgery, the First
Affiliated Hospital of Nanjing Medical University, Nanjing, China, 6 Institute of Tumor Biology, Jiangsu Province Academy of Clinical Medicine, Nanjing, China
Abstract
Gastric cancer remains the second leading cause of cancer-related death in the world. H. pylori infection, a major risk factor
for gastric cancer, generates high levels of reactive oxygen species (ROS). Glutathione peroxidase 3 (GPX3), a plasma GPX
member and a major scavenger of ROS, catalyzes the reduction of hydrogen peroxide and lipid peroxides by reduced
glutathione. To study the expression and gene regulation of GPX3, we examined GPX3 gene expression in 9 gastric cancer
cell lines, 108 primary gastric cancer samples and 45 normal gastric mucosa adjacent to cancers using quantitative real-time
RT-PCR. Downregulation or silencing of GPX3 was detected in 8 of 9 cancer cell lines, 83% (90/108) gastric cancers samples,
as compared to non-tumor adjacent normal gastric samples
您可能关注的文档
- sepsid even-skipped enhancers are functionally conserved in drosophila despite lack of sequence conservationsepsid甚至没有增强剂是在果蝇尽管缺乏序列功能守恒的.pdf
- separation of recombination and sos response in escherichia coli reca suggests lexa interaction sites分离重组大肠杆菌reca和sos反应表明lexa互动网站.pdf
- separating wheat from chaff in plant genomes小麦从谷壳分离植物基因组中.pdf
- septins regulate bacterial entry into host cellsseptins调节细菌进入宿主细胞.pdf
- separation of fnirs signals into functional and systemic components based on differences in hemodynamic modalitiesfnirs信号划分成不同的功能和系统组件基于血流动力学模式的差异.pdf
- sentinel surveillance of influenza-like illness in two hospitals in maracay, venezuela 2006–2010哨点监测流感样疾病在马拉凯两家医院中,委内瑞拉2006 - 2010.pdf
- sequence analysis of pkf3-70 in klebsiella pneumoniae probable origin from r100-like plasmid of escherichia coli序列分析pkf3 - 70的肺炎克雷伯菌可能起源r100-like大肠杆菌的质粒.pdf
- sequence alignment reveals possible mapk docking motifs on hiv proteins序列比对显示可能mapk对接主题关于艾滋病毒的蛋白质.pdf
- sequence composition and gene content of the short arm of rye (secale cereale) chromosome 1组成和基因序列的内容短臂黑麦(secale cereale)染色体1.pdf
- separating sisters shugoshin protects sa2 at centromeres but not at chromosome arms分离的姐妹shugoshin保护sa2在染色体着丝粒而不是武器.pdf
- silencing of the rotavirus nsp4 protein decreases the incidence of biliary atresia in murine model沉默的轮状病毒nsp4蛋白质减少胆道闭锁的发病率在小鼠模型中.pdf
- silencing of xb130 is associated with both the prognosis and chemosensitivity of gastric cancer沉默的xb130与胃癌的预后和化学敏感性.pdf
- silencing of pink1 expression affects mitochondrial dna and oxidative phosphorylation in dopaminergic cells沉默的pink1表达影响线粒体dna和多巴胺能细胞的氧化磷酸化.pdf
- silencing prion protein in mda-mb-435 breast cancer cells leads to pleiotropic cellular responses to cytotoxic stimuli沉默朊蛋白在乳腺癌mda - mb - 435细胞导致细胞毒性刺激的多效性的细胞反应.pdf
- silent but not static accelerated base-pair substitution in silenced chromatin of budding yeasts沉默但不是静态加速碱基对替换沉默染色质的出芽酵母.pdf
- significant type i and type iii collagen production from human periodontal ligament fibroblasts in 3d peptide scaffolds without extra growth factors重要的i型和iii型胶原蛋白生产从人类牙周韧带成纤维细胞在3 d肽支架没有额外的生长因子.pdf
- silencing viral infection抑制病毒感染.pdf
- silencing relaxin-3 in nucleus incertus of adult rodents a viral vector-based approach to investigate neuropeptide function沉默的原子核incertus relaxin-3成年啮齿动物病毒研究神经肽功能的基于矢量的方法.pdf
- silent synapses, ltp, and the indirect parallel-fibre pathway computational consequences of optimal cerebellar noise-processing沉默突触,ltp和间接parallel-fibre路径计算最优小脑noise-processing的后果.pdf
- silibinin inhibits hiv-1 infection by reducing cellular activation and proliferationsilibinin抑制hiv - 1感染通过减少细胞的激活和增殖.pdf
文档评论（0）