silencing viral infection抑制病毒感染.pdfVIP

Research in Translation Silencing Viral Infection Derek M. Dykxhoorn, Judy Lieberman* The Need for New Antiviral mechanism to prevent or treat viral endogenous gene silencing operates Therapies infection. through multiple mechanisms, including mRNA cleavage, inhibition Viruses are formidable targets for drug How RNAi Works of translation, and epigenetic development. As obligate intracellular RNAi uses small double-stranded modifi cations of chromatin, mRNA parasites that take over the host RNAs to silence genes bearing a cleavage is the most effi cient cellular machinery to further their own complementary sequence. Although mechanism and is the mechanism agenda, they seem to understand the being harnessed for antiviral therapies. intimate workings of cellular pathways Small RNAs, either exogenous better than those seeking to develop small interfering RNAs (siRNAs) or treatments against them. It is diffi cult to inactivate a virus without doing harm Five Key Papers on Harnessing