site and strain-specific variation in gut microbiota profiles and metabolism in experimental mice网站和毒株特异性变异在实验小鼠肠道微生物群的概要文件和新陈代谢.pdfVIP

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site and strain-specific variation in gut microbiota profiles and metabolism in experimental mice网站和毒株特异性变异在实验小鼠肠道微生物群的概要文件和新陈代谢.pdf

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site and strain-specific variation in gut microbiota profiles and metabolism in experimental mice网站和毒株特异性变异在实验小鼠肠道微生物群的概要文件和新陈代谢

Site and Strain-Specific Variation in Gut Microbiota Profiles and Metabolism in Experimental Mice 1 3,4 2 3,4 2 Melissa K. Friswell , Helen Gika , Ian J. Stratford , Georgios Theodoridis , Brian Telfer , Ian D. 3 1 Wilson , Andrew J. McBain * 1 Microbiology Research Group, School of Pharmacy and Pharmaceutical Sciences, The University of Manchester, Manchester, United Kingdom, 2 Experimental Oncology Research Group, School of Pharmacy and Pharmaceutical Sciences, The University of Manchester, Manchester, United Kingdom, 3 AstraZeneca, Department of Clinical Pharmacology, Drug Metabolism and Pharmacokinetics, Macclesfield, United Kingdom, 4 Department of Chemistry, Aristotle University of Thessaloniki, Thessaloniki, Greece Abstract Background: The gastrointestinal tract microbiota (GTM) of mammals is a complex microbial consortium, the composition and activities of which influences mucosal development, immunity, nutrition and drug metabolism. It remains unclear whether the composition of the dominant GTM is conserved within animals of the same strain and whether stable GTMs are selected for by host-specific factors or dictated by environmental variables. Methodology/Principal Findings: The GTM composition of six highly inbred, genetically distinct strains of mouse (C3H, C57, GFEC, CD1, CBA nu/nu and SCID) was profiled using eubacterial –specific PCR-DGGE and quantitative PCR of feces. Animals exhibited strain-specific fecal eubacterial profiles that were highly stable (c. .95% concordance over 26 months for C57). Analyses of mice that had been relocated before and after maturity