PCNA,Ki67，p53蛋白及βHCG在宫颈鳞癌中表达及临床病理意.docVIP

PCNA,Ki67，p53蛋白及βHCG在宫颈鳞癌中表达及临床病理意 　 作者：孙咏梅， 陈迎秀， 贾惠英， 王宇为， 谢秋红 【摘要】 目的： 探讨增殖细胞核抗原（PCNA）,Ki67，p53蛋白及βHCG在宫颈鳞癌中的表达及其临床病理意义。方法： 采用免疫组化方法检测不同临床分期、不同病理分级的55例宫颈鳞癌标本中PCNA,Ki67，p53及βHCG的表达情况。结果： PCNA，Ki67，p53蛋白在宫颈鳞癌中的表达率高于慢性宫颈炎，表达差异有统计学意义（Plt;0.05），在Ⅲ级鳞癌及有淋巴结转移者中的表达率高于Ⅰ级、Ⅱ级鳞癌及无淋巴结转移者，差异有统计学意义（Plt;0.05）；βHCG在宫颈鳞癌中的表达率高于慢性宫颈炎，在中晚期宫颈癌及有淋巴结转移者中的表达高于早期宫颈癌及无淋巴结转移者，差异有统计学意义（Plt;0.05）。结论： PCNA，Ki67，p53蛋白的表达率与宫颈癌的病理分级及淋巴结转移有关；βHCG表达率与宫颈癌的临床分期及淋巴结转移有关；PCNA ，Ki67, p53，βHCG与宫颈癌的预后有关。 【关键词】 子宫颈鳞癌； PCNA； Ki67； p53蛋白； βHCG；免疫组化 ［Abstract］ Objective: To investigate the expressions of PCNA, Ki67, p53 and βHCG in squamous cell carcinoma of the cervix(SCC) and their clinic pathologic significance. Methods： The expressions of PCNA，Ki67，p53 and βHCG in 55 cases of squamous cell carcinoma of the cervix were detected by immunohistochemistry. Results： The expressions of PCNA,Ki67 and p53 in SCC were higher than those in chronic cervicitis（Plt;0.05）. The expressions of PCNA,Ki67 and p53 in squamous cell histological types Ⅲ group, lymph node metastasis group were higher than those in squamous cell histological types Ⅰ,Ⅱgroup, no metastasis group（Plt;0.05）. The expressions of βHCG in SCC were higher than those in chronic cervicitis（Plt;0.05）.The expressions of βHCG in advanced stage group(clinical stageⅡ，Ⅲ), lymph node metastasis group were higher than those in early stage group(clinical stage 0,Ⅰ), no metastasis group（Plt;0.05）. Conclusion： The expressions of PCNA, Ki67 and p53 in SCC were associated both with histological grade and lymph node metastasis. The expressions of βHCG in SCC were associated both with clinical stage and lymph node metastasis. The expressions of PCNA，Ki67, p53，βHCG were associated with the prognosis of SCC. ［Key words］ squamous cell carcinoma of the cervix; PCNA; Ki67; p53; βHCG; immunohistochemistry 子宫颈鳞状细胞癌（squamous cell carcinoma of the cervix,SCC）是世界上发病率仅次于乳腺癌的女性第二常见肿瘤，目前仍是女性生殖系统发病率最高的恶性肿瘤，而且近年来发病者趋于年轻化，严重危害女性生理、心理健康。已有多项