不同剂量纳络酮治疗脑出血对患者神经元保护作用.docVIP

不同剂量纳络酮治疗脑出血对患者神经元保护作用 　【关键词】 脑出血 Study on neuronprotective effect of different doses of naloxone in patients with intracerebral hemorrhage 　　【Abstract】 AIM: To explore the doseeffect relationship of neuronprotective effect of different doses of naloxone in patients with intracerebral hemorrhage. METHODS: One hundred and twenty patients were randomly divided into 3 groups of 40 cases each: high dose (H), medium dose (M) and low dose (L) groups. The hematoma volume and edemazone areas, the level of neuron specific enolase (NSE) in serum, nervefunctiondefect score and the ADL score were examined at particular time respectively. RESULTS: ① There were significant differences in the hematoma volume and edemazone area at different times points within a group (P＜0.001). However, among different groups, the hematoma volume of L group was larger than those of H and M groups at 10 d (Plt;0.001) and the edemazone area of L group was larger than that of M and H groups（P＜0.002). But at 20 d, there was no significant difference in the hematoma volume and edemazone area among the 3 groups. ② There was an increase of NSE in serum at 12 h after hemorrhage in all the patients. Moreover, NSE significantly decreased at 20 d and there were significant differences among the groups. The level of NSE in H group was lower than that in M group and that in M group was lower than that in L group（Plt;0.001）. ③ The nervefunctiondefect scores of H group was higher than those of M group and L group at 20 d（Plt;0.02）. The ADL scores of H group was higher than that of M group and the score of M group was higher than that of L group at 3 mo（Plt;0.001）. CONCLUSION: Therapy with naloxone of 0.3 mg/(kg#12539;d) each day can protect neurons, decrease the function defect and improve living conditions in patients with intracerebral hemorrhage. 　　【Keywords】 cerebral hemorrhage; Naloxone; doseresponse relationship, drug; phosphopyruvate hydratase 　　【摘要】 目的： 探讨不同剂量纳络酮治疗脑出血对其神经功能保护作用的量效关系. 方法： 脑出血患者120例，随机分为纳