a crossover study of short burst oxygen therapy (sbot) for the relief of exercise-induced breathlessness in severe copd的交叉研究短脉冲氧疗法(sbot)缓解运动性呼吸困难严重慢性阻塞性肺病.pdfVIP

O’Driscoll et al. BMC Pulmonary Medicine 2011, 11:23 /1471-2466/11/23 RESEARCH ARTICLE Open Access A crossover study of short burst oxygen therapy (SBOT) for the relief of exercise-induced breathlessness in severe COPD * B Ronan O’Driscoll , Jane Neill, Siddiq Pulakal and Peter M Turkington Abstract Background: Previous small studies suggested SBOT may be ineffective in relieving breathlessness after exercise in COPD. Methods: 34 COPD patients with FEV1 40% predicted and resting oxygen saturation ≥93% undertook an exercise step test 4 times. After exercise, patients were given 4 l/min of oxygen from a simple face mask, 4 l/min air from a face mask (single blind), air from a fan or no intervention. Results: Average oxygen saturation fell from 95.0% to 91.3% after exercise. The mean time to subjective recovery was 3.3 minutes with no difference between treatments. The mean Borg breathlessness score was 1.5/10 at rest, rising to 5.1/10 at the end of exercise (No breathlessness = 0, worst possible breathlessness = 10). Oxygen therapy had no discernable effect on Borg scores even for 14 patients who desaturated below 90%. 15 patients had no preferred treatment, 7 preferred oxygen, 6 preferred the fan, 3 preferred air via a mask and 3 preferred room air. Conclusions: This study provides no support for the idea that COPD patients who are not hypoxaemic at rest derive noticeable benefit from oxygen therapy after exercise. Use of air from a mask or from a fan had no apparent physiological or placebo effect. Background commonly, after exercise by patients with COPD who Oxygen therapy is beneficial for many patients with are not hypoxaemic at rest. This form of treatment chronic obstructive pulmonary disea