胰岛素样生长因子1及糖尿病下肢血管病变关系.docVIP

胰岛素样生长因子1及糖尿病下肢血管病变关系 　 作者：徐静，张春虹，王俊宏，王学良，袁晓红，张喜民 【摘要】 目的 分析 血清胰岛素样生长因子1(IGF1)水平在2型糖尿病下肢血管病变中的变化 规律 ，探讨IGF1在糖尿病大血管病变发病机制中的作用，为糖尿病大血管病变的防治提供依据。 方法 选择74例2型糖尿病患者和15例健康人，常规测身高、体重、血压、血糖、空腹胰岛素、糖化血红蛋白、血脂、尿白蛋白排泄率；用ELISA法测血清IGF1水平；用多普勒超声进行双下肢动脉病变检查。结果 ①糖尿病患者血清IGF1水平明显高于对照组；②糖尿病合并下肢动脉血管病变时血清IGF1水平明显高于无下肢动脉血管病变组，且血清IGF1水平与下肢动脉血管病变的严重程度呈正相关；③糖尿病下肢动脉血管病变的严重程度与尿白蛋白排泄率、病程、血总胆固醇(TC)、低密度脂蛋白(LDL)水平呈正相关。结论 血清IGF1水平可以反映糖尿病下肢血管病变的严重程度，对糖尿病大血管病变的诊断有 参考 价值，并有可能作为糖尿病大血管病变 治疗 的新靶点。 论文代写 【关键词】 胰岛素样生长因子1；糖尿病；下肢血管病变；大血管病变 　　Relationship between insulinlike growth factor　and diabetic lower extremity angiopathy 　　ABSTRACT: Objective To analyze the changes of insulinlike growth factor1 (IGF1) serum level in diabetic lower extremity angiopathy, explore the role of IGF1 in the pathogenesis of diabetic vascular complications, and provide basis for prevention and treatment of diabetic angiopathy. Methods We selected 74 type 2 diabetes mellitus (T2DM) patients as case group and 15 normal people as control group. All of the research subjects were measured in hEight, wEIght, blood pressure, blood glucose, blood lipid, fast insulin, and urinary albumin excretion rate (UAER). The serum IGF1 level was measured with ELISA. Arteries of both lower extremities were measured with color Doppler flow image. Results ① The serum IGF1 level was significantly higher in DM patients than in control group. ② The serum IGF1 level was significantly higher in diabetic patients with lower extremities arterial vasculopathy than diabetic patients without. The results showed a positive correlation between the serum IGF1 level and severity of lower extremity arterial vasculopathy. ③ There was a positive correlation between diabetic duration, UAER, total cholesterol (TC), lower density lipoprotein (LDL) in blood and lower extremity arterial vasculopathy in diabetic patients. Conclusion The serum IGF1 level can reflect the severity of lower extremity arterial vasculopathy. The serum IGF1 l