automatic extraction of gene ontology annotation and its correlation with clusters in protein networks自动提取基因本体论注释及其与集群相关的蛋白质网络.pdfVIP

BMC Bioinformatics BioMed Central Research article Open Access Automatic extraction of gene ontology annotation and its correlation with clusters in protein networks Nikolai Daraselia, Anton Yuryev*, Sergei Egorov, Ilya Mazo and Iaroslav Ispolatov Address: Ariadne Genomics, Inc, 9430 Key West Ave., Suite 313, Rockville, MD 20850, USA Email: Nikolai Daraselia - nikolai@; Anton Yuryev* - ayuryev@; Sergei Egorov - esl@; Ilya Mazo - mazo@; Iaroslav Ispolatov - slava@ * Corresponding author Published: 10 July 2007 Received: 29 September 2006 Accepted: 10 July 2007 BMC Bioinformatics 2007, 8:243 doi:10.1186/1471-2105-8-243 This article is available from: /1471-2105/8/243 © 2007 Daraselia et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Abstract Background: Uncovering cellular roles of a protein is a task of tremendous importance and complexity that requires dedicated experimental work as well as often sophisticated data mining and processing tools. Protein functions, often referred to as its annotations, are believed to manifest themselves through topology of the networks of inter-proteins interactions. In particular, there is a growing body of evidence that proteins performing the same function are more likely to interact with each other than with proteins with other functions.