原创力文档- 1、原创力文档（book118）网站文档一经付费（服务费），不意味着购买了该文档的版权，仅供个人/单位学习、研究之用，不得用于商业用途，未经授权，严禁复制、发行、汇编、翻译或者网络传播等，侵权必究。。
- 2、本站所有内容均由合作方或网友上传，本站不对文档的完整性、权威性及其观点立场正确性做任何保证或承诺！文档内容仅供研究参考，付费前请自行鉴别。如您付费，意味着您自己接受本站规则且自行承担风险，本站不退款、不进行额外附加服务；查看《如何避免下载的几个坑》。如果您已付费下载过本站文档，您可以点击 这里二次下载。
- 3、如文档侵犯商业秘密、侵犯著作权、侵犯人身权等，请点击“版权申诉”（推荐），也可以打举报电话：400-050-0827(电话支持时间：9:00-18:30)。
- 4、该文档为VIP文档，如果想要下载，成为VIP会员后，下载免费。
- 5、成为VIP后，下载本文档将扣除1次下载权益。下载后，不支持退款、换文档。如有疑问请联系我们。
- 6、成为VIP后，您将拥有八大权益，权益包括：VIP文档下载权益、阅读免打扰、文档格式转换、高级专利检索、专属身份标志、高级客服、多端互通、版权登记。
- 7、VIP文档为合作方或网友上传，每下载1次， 网站将根据用户上传文档的质量评分、类型等，对文档贡献者给予高额补贴、流量扶持。如果你也想贡献VIP文档。上传文档
查看更多
interferon-β for treatment of rheumatoid arthritisinterferon-β用于治疗风湿性关节炎
Arthritis Research Vol 4 No 6 van Holten et al.
Review
Interferon-ββ for treatment of rheumatoid arthritis?
Judith van Holten, Christine Plater-Zyberk and Paul P Tak
Division of Clinical Immunology and Rheumatology Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
Corresponding author: Paul P Tak (e-mail: P.P.Tak@amc.uva.nl)
Received: 15 August 2002 Accepted: 27 August 2002 Published: 18 September 2002
Arthritis Res 2002, 4:346-352 (DOI 10.1186/ar598)
© 2002 BioMed Central Ltd (Print ISSN 1465-9905; Online ISSN 1465-9913)
Abstract
IFN-β treatment is emerging as a potentially effective form of therapy in various immune-mediated
conditions. The present review addresses the possible role of IFN-β in immune-mediated diseases
such as multiple sclerosis and rheumatoid arthritis. Several placebo-controlled trials are discussed, as
are the available immunological data that are relevant to this field. Review of these data provides
evidence that IFN-β has some beneficial therapeutic effect in patients with relapsing-remitting multiple
sclerosis and might also have antirheumatic potential. This notion is supported by recent studies
showing a critical role for IFN-β in bone homeostasis.
Keywords: IFN-β, multiple sclerosis, rheumatoid arthritis
Introduction sclerosis (MS). IFN-γ was used in a multicentre, random-
IFNs are a family of naturally secreted proteins with ized, double-blind trial in 19
您可能关注的文档
- hiv prevalence among aboriginal british columbians艾滋病毒流行率在原住民不列颠哥伦比亚人.pdf
- hiv master of the host cell艾滋病毒的宿主细胞.pdf
- hiv and hepatitis c virus infections among hanka injection drug users in central ukraine a cross-sectional survey艾滋病毒和丙型肝炎病毒感染hanka注射吸毒者在乌克兰中部一个横断面调查.pdf
- hiv prevalence in severely malnourished children admitted to nutrition rehabilitation units in malawi geographical & seasonal variations a cross-sectional study艾滋病毒流行率严重营养不良的儿童承认营养康复单元在马拉维地理和季节变化一个横断面研究.pdf
- hiv prevalence and risk behaviours among injecting drug users in six indonesian cities implications for future hiv prevention programs注射吸毒者中艾滋病毒流行率和风险行为六个印尼城市对未来的艾滋病毒预防方案的影响.pdf
- hiv transmission as a result of drug market violence a case report艾滋病毒传播由于毒品市场暴力案例报告.pdf
- hiv seroprevalence among participants at a supervised injection facility in vancouver, canada implications for prevention, care and treatment艾滋病毒seroprevalence参与者在监督注塑设备在温哥华,加拿大对预防、护理和治疗.pdf
- hiv prevention for south african youth which interventions work a systematic review of current evidence对南非的艾滋病预防青年干预工作系统回顾当前的证据.pdf
- hiv-1 drug resistance genotyping from antiretroviral therapy (art) na？ve and first-line treatment failures in djiboutian patientshiv - 1型耐药性从抗逆转录病毒疗法(art)na ve和吉患者的一线治疗失败.pdf
- hiv, appendectomy and postoperative complications at a reference hospital in northwest tanzania cross-sectional study参考医院的艾滋病,阑尾切除术,术后并发症在坦桑尼亚西北部的横断面研究.pdf
- interfacing systems biology and synthetic biology接口系统生物学与合成生物学.pdf
- interferon-induced protein ifit4 is associated with systemic lupus erythematosus and promotes differentiation of monocytes into dendritic cell-like cells干扰素诱导蛋白ifit4与系统性红斑狼疮和促进单核细胞向树突状细胞样的细胞的分化.pdf
- interface design for cmos-integrated electrochemical impedance spectroscopy (eis) biosensors界面设计cmos集成电化学阻抗谱(eis)生物传感器.pdf
- inter-hospital transport of critically ill patients; expect surprises跨基础运输危重病人;.pdf
- interferon-β attenuates lung inflammation following experimental subarachnoid hemorrhageinterferon-β变弱实验性蛛网膜下腔出血后肺部炎症.pdf
- interferon-λ in hcv infection and therapy ？interferon-λ丙肝病毒感染和治疗.pdf
- interferon-γ inhibits interleukin-1β-induced matrix metalloproteinase production by synovial fibroblasts and protects articular cartilage in early arthritisinterferon-γ抑制interleukin-1β-induced滑膜成纤维细胞基质金属蛋白酶的生产和保护关节软骨在早期关节炎.pdf
- interindividual and intercellular polymorphisms of ag-nor pattern in mink embryo siblings个人间和细胞间多态性ag-nor模式貂胚胎的兄弟姐妹.pdf
- interferon-lambda1 induces peripheral blood mononuclear cell-derived chemokines secretion in patients with systemic lupus erythematosus its correlation with disease activityinterferon-lambda1诱发外周血单核细胞衍生趋化因子的分泌在系统性红斑狼疮患者与疾病活动的相关性.pdf
- inter-individual variations of human mercury exposure biomarkers a cross-sectional assessmentinter-individual人类汞暴露生物标志物横断面评估的变化.pdf
文档评论（0）