原创力文档most recent developments in strategies to reduce the progression of structural changes in osteoarthritis today and tomorrow最近的发展策略来减少结构性变化在骨关节炎的进展的今天和明天.pdfVIP
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most recent developments in strategies to reduce the progression of structural changes in osteoarthritis today and tomorrow最近的发展策略来减少结构性变化在骨关节炎的进展的今天和明天
Available online /content/8/2/206
Review
Most recent developments in strategies to reduce the
progression of structural changes in osteoarthritis:
today and tomorrow
Jean-Pierre Pelletier, Johanne Martel-Pelletier and Jean-Pierre Raynauld
Osteoarthritis Research Unit, University of Montreal Hospital Centre, Notre-Dame Hospital, Montreal, Quebec, Canada
Corresponding author: Jean-Pierre Pelletier, dr@jppelletier.ca
Published: 21 March 2006 Arthritis Research Therapy 2006, 8:206 (doi:10.1186/ar1932)
This article is online at /content/8/2/206
© 2006 BioMed Central Ltd
Abstract of effective treatments. The disease develops and changes
Osteoarthritis (OA), the most common of all arthritic conditions, is slowly, and clinically represents a heterogeneous group of
a social and financial burden to all nations. The most recent disorders that are often referred to as osteoarthritic diseases.
research has significantly advanced our understanding of the The absence of objective and definitive biochemical markers
cause of OA and risk factors associated with it. These findings has also been a major hurdle for clinical and therapeutic
have provided useful information that has helped in the daily research.
management of patients with OA. Some preventative measures
and a number of therapeutic agents and drugs are available, which
may help to reduce the progression of OA in certain patients. The development of disease-modifying osteoarthritis drugs
Moreover, the most recent progress in research has significantly (DMOADs) is a rather complex process. A number of
enhanced our knowledge
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