neural set point for the control of arterial pressure role of the nucleus tractus solitarius神经控制的设定值的动脉压作用核束solitarius.pdfVIP

Zanutto et al. BioMedical Engineering OnLine 2010, 9:4 /content/9/1/4 REVIEW Open Access Neural set point for the control of arterial pressure: role of the nucleus tractus solitarius 1,2* 1 2 B Silvano Zanutto , Max E Valentinuzzi , Enrique T Segura * Correspondence: silvano@fi.uba.ar Abstract 1Instituto de Ingeniería Biomédica (IIBM), Facultad de Ingeniería (FI) Background: Physiological experiments have shown that the mean arterial blood Universidad de Buenos Aires (UBA), Av Paseo Colón 850, C1063ACV, pressure (MAP) can not be regulated after chemo and cardiopulmonary receptor Buenos Aires, Argentina denervation. Neuro-physiological information suggests that the nucleus tractus solitarius (NTS) is the only structure that receives information from its rostral neural nuclei and from the cardiovascular receptors and projects to nuclei that regulate the circulatory variables. Methods: From a control theory perspective, to answer if the cardiovascular regulation has a set point, we should find out whether in the cardiovascular control there is something equivalent to a comparator evaluating the error signal (between the rostral projections to the NTS and the feedback inputs). The NTS would function as a comparator if: a) its lesion suppresses cardiovascular regulation; b) the negative feedback loop still responds normally to perturbations (such as mechanical or