neural temporal dynamics of stress in comorbid major depressive disorder and social anxiety disorder神经的时间动态压力共病重度抑郁症和社交焦虑症.pdfVIP

Waugh et al. Biology of Mood Anxiety Disorders 2012, 2:11 /content/2/1/11 Biology of Mood Anxiety Disorders RESEARCH Open Access Neural temporal dynamics of stress in comorbid major depressive disorder and social anxiety disorder 1* 2 2 3 2 Christian E Waugh , J Paul Hamilton , Michael C Chen , Jutta Joormann and Ian H Gotlib Abstract Background: Despite advances in neurobiological research on Major Depressive Disorder and Social Anxiety Disorder, little is known about the neural functioning of individuals with comorbid depression/social anxiety. We examined the timing of neural responses to social stress in individuals with major depression and/or social anxiety. We hypothesized that having social anxiety would be associated with earlier responses to stress, having major depression would be associated with sustained responses to stress, and that comorbid participants would exhibit both of these response patterns. Methods: Participants were females diagnosed with pure depression (n = 12), pure social anxiety (n = 16), comorbid depression/social anxiety (n = 17), or as never having had any Axis-I disorder (control; n = 17). Blood oxygenation-level dependent activity (BOLD) was assessed with functional magnetic resonance imaging (fMRI). To induce social stress, participants prepared a speech that was ostensibly to be evaluated by a third party. Results: Whereas being diagnosed with depression was associated with a resurgence of activation in the medial frontal cortex late in the stressor, ha