原创力文档neuroactive multifunctional tacrine congeners with cholinesterase, anti-amyloid aggregation and neuroprotective properties刺激神经组织的多功能他克林与胆碱酯酶同系物,种抗体聚合和神经保护属性.pdfVIP
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neuroactive multifunctional tacrine congeners with cholinesterase, anti-amyloid aggregation and neuroprotective properties刺激神经组织的多功能他克林与胆碱酯酶同系物,种抗体聚合和神经保护属性
Pharmaceuticals 2011, 4, 382-418; doi:10.3390/ph4020382
OPEN ACCESS
pharmaceuticals
ISSN 1424-8247
/journal/pharmaceuticals
Review
Neuroactive Multifunctional Tacrine Congeners with
Cholinesterase, Anti-Amyloid Aggregation and Neuroprotective
Properties
Maria Kozurkova 1,*, Slavka Hamulakova 2, Zuzana Gazova 3, Helena Paulikova 4 and
2
Pavol Kristian
1 Department of Biochemistry, Institute of Chemistry, P. J. Šafárik University, Moyzesova 11, Košice,
Slovakia
2 Department of Organic Chemistry, Institute of Chemistry, P. J. Šafárik University, Moyzesova 11,
Košice, Slovakia; E-Mails: slavka.hamulakova@upjs.sk (S.H.); pavol.kristian@upjs.sk (P.K.)
3 Department of Biophysics, Institute of Experimental Physics, Slovak Academy of Sciences,
Watsonova 47, Košice, Slovakia; E-Mail: gazova@saske.sk (Z.G.)
4 Department of Biochemistry and Microbiology, Faculty of Chemical and Food Technology, Slovak
University of Technology, Radlinského 9, Bratislava, Slovakia;
E-Mail: helena.paulikova@stuba.sk (H.P.)
* Author to whom correspondence should be addressed; E-Mail: maria.kozurkova@upjs.sk;
Tel.: +421-556-223-582; Fax: +421-556-222-124.
Received: 29 December 2010; in revised form: 3 February 2011 / Accepted: 12 February 2011 /
Published: 18 February 2011
Abstract: The review summarizes research into the highly relevant topics of cholinesterase
and amyloid aggregation inhibitors connected to tacrine congeners, both of which are
associated with neurogenerative diseases. Various opinions will be discussed regarding the
dual b
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