neural networks engaged in tactile object manipulation patterns of expression among healthy individuals神经网络从事健康个体之间的触觉对象操作的模式表达式.pdfVIP

Kägi et al. Behavioral and Brain Functions 2010, 6:71 /content/6/1/71 RESEARCH Open Access Neural networks engaged in tactile object manipulation: patterns of expression among healthy individuals 1 2 1 3 1,4* Georg Kägi , John H Missimer , Eugenio Abela , Rüdiger J Seitz , Bruno J Weder Abstract Background: Somatosensory object discrimination has been shown to involve widespread cortical and subcortical structures in both cerebral hemispheres. In this study we aimed to identify the networks involved in tactile object manipulation by principal component analysis (PCA) of individual subjects. We expected to find more than one network. Methods: Seven healthy right-handed male volunteers (aged 22 to 44 yrs) manipulated with their right hand aluminium spheres during 5 s with a repetition frequency of 0.5-0.7 Hz. The correlation coefficients between the principal component temporal expression coefficients and the hemodynamic response modelled by SPM (ecc) determined the task-related components. To establish reproducibility within subjects and similarity of functional connectivity patterns among subjects, regional correlation coefficients (rcc) were computed between task-related component image volumes. By hierarchically categorizing, selecting and averaging the task-related component image volumes across subjects according to the rccs, mean component images (MCIs) were derived describing neural networks associated with tactile object manipulation. Results: Two independent mean component images emerged. Each included the primary sensorimotor cortex contralateral to the manipulating hand. The region extended to the premotor cortex in MCI 1, whereas it was restricted to the hand area of the primary sensorimotor cortex in MCI