原创力文档neurodevelopmental toxicity of prenatal polychlorinated biphenyls (pcbs) by chemical structure and activity a birth cohort study神经发育毒性产前多氯联苯(pcb)的化学结构和活动出生队列研究.pdfVIP
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neurodevelopmental toxicity of prenatal polychlorinated biphenyls (pcbs) by chemical structure and activity a birth cohort study神经发育毒性产前多氯联苯(pcb)的化学结构和活动出生队列研究
Park et al. Environmental Health 2010, 9:51
/content/9/1/51
RESEARCH Open Access
Neurodevelopmental toxicity of prenatal
polychlorinated biphenyls (PCBs) by chemical
structure and activity: a birth cohort study
1 1* 2 2 2 2
Hye-Youn Park , Irva Hertz-Picciotto , Eva Sovcikova , Anton Kocan , Beata Drobna , Tomas Trnovec
Abstract
Background: Polychlorinated biphenyls (PCBs) are ubiquitous environmental toxins. Although there is growing
evidence to support an association between PCBs and deficits of neurodevelopment, the specific mechanisms are
not well understood. The potentially different roles of specific PCB groups defined by chemical structures or
hormonal activities e.g., dioxin-like, non-dioxin like, or anti-estrogenic PCBs, remain unclear. Our objective was to
examine the association between prenatal exposure to defined subsets of PCBs and neurodevelopment in a cohort
of infants in eastern Slovakia enrolled at birth in 2002-2004.
Methods: Maternal and cord serum samples were collected at delivery, and analyzed for PCBs using high-
resolution gas chromatography. The Bayley Scales of Infant Development -II (BSID) were administered at 16 months
of age to over 750 children who also had prenatal PCB measurements.
Results: Based on final multivariate-adjusted linear regression model, maternal mono-ortho-substituted PCBs were
significantly associated with lower scores on both the psychomotor (PDI) and mental development indices (MDI).
Also a significant association between cord mono-ortho-substituted PCBs and reduced PDI was observed, but the
association with MDI was marginal (p = 0.05). Anti-estrogenic and di-ortho-substituted PCBs did not show any
statistically significant association
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