原创力文档neurobehavioral function and low-level exposure to brominated flame retardants in adolescents a cross-sectional study神经行为功能和低级暴露在溴化阻燃剂在青少年一个横断面研究.pdfVIP
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neurobehavioral function and low-level exposure to brominated flame retardants in adolescents a cross-sectional study神经行为功能和低级暴露在溴化阻燃剂在青少年一个横断面研究
Kiciński et al. Environmental Health 2012, 11:86
/content/11/1/86
RESEARCH Open Access
Neurobehavioral function and low-level exposure
to brominated flame retardants in adolescents:
a cross-sectional study
1 2 3 3,4 5 5 6
Michał Kiciński , Mineke K Viaene , Elly Den Hond , Greet Schoeters , Adrian Covaci , Alin C Dirtu , Vera Nelen ,
7 8 9 8 10 1,11*
Liesbeth Bruckers , Kim Croes , Isabelle Sioen , Willy Baeyens , Nicolas Van Larebeke and Tim S Nawrot
Abstract
Background: Animal and in vitro studies demonstrated a neurotoxic potential of brominated flame retardants, a
group of chemicals used in many household and commercial products to prevent fire. Although the first reports of
detrimental neurobehavioral effects in rodents appeared more than ten years ago, human data are sparse.
Methods: As a part of a biomonitoring program for environmental health surveillance in Flanders, Belgium, we
assessed the neurobehavioral function with the Neurobehavioral Evaluation System (NES-3), and collected blood
samples in a group of high school students. Cross-sectional data on 515 adolescents (13.6-17 years of age) was
available for the analysis. Multiple regression models accounting for potential confounders were used to investigate
the associations between biomarkers of internal exposure to brominated flame retardants [serum levels of
polybrominated diphenyl ether (PBDE) congeners 47, 99, 100, 153, 209, hexabromocyclododecane (HBCD), and
tetrabromobisphenol A (TBBPA)] and cognitive performance. In addition, we investigated the association be
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