norepinephrine to increase blood pressure in endotoxaemic pigs is associated with improved hepatic mitochondrial respiration去甲肾上腺素增加血压endotoxaemic猪与改善肝线粒体呼吸.pdfVIP

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norepinephrine to increase blood pressure in endotoxaemic pigs is associated with improved hepatic mitochondrial respiration去甲肾上腺素增加血压endotoxaemic猪与改善肝线粒体呼吸.pdf

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norepinephrine to increase blood pressure in endotoxaemic pigs is associated with improved hepatic mitochondrial respiration去甲肾上腺素增加血压endotoxaemic猪与改善肝线粒体呼吸

Available online /content/12/4/R88 Vol 12 No 4 Open Access Research Norepinephrine to increase blood pressure in endotoxaemic pigs is associated with improved hepatic mitochondrial respiration 1 2 1 2 1 Tomas Regueira , Bertram Bänziger , Siamak Djafarzadeh , Sebastian Brandt , Jose Gorrasi , 1 1 1 Jukka Takala , Philipp M Lepper and Stephan M Jakob 1Department of Intensive Care Medicine, Bern University Hospital (Inselspital) and University of Bern, Freiburgstrasse, CH-3010 Bern, Switzerland 2Department of Anesthesiology and Pain Therapy, Bern University Hospital (Inselspital) and University of Bern, Freiburgstrasse, CH-3010 Bern, Switzerland Corresponding author: Stephan M Jakob, stephan.jakob@insel.ch Received: 22 Apr 2008 Revisions requested: 15 May 2008 Revisions received: 30 May 2008 Accepted: 14 Jul 2008 Published: 14 Jul 2008 Critical Care 2008, 12:R88 (doi:10.1186/cc6956) This article is online at: /content/12/4/R88 © 2008 Regueira et al.; licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Abstract Introduction Low blood pressure, inadequate tissue oxygen 232) in controls (P = 0.002), and from 107 (84 to 132) to 161 delivery and mitochondrial dysfunction have all been implicated (147 to 340) in norepinephrine-treate