quantification of atopy, lung function and airway hypersensitivity in adults量化的特异反应性、肺功能和成人呼吸道过敏.pdfVIP

Marinho et al. Clinical and Translational Allergy 2011, 1:16 /content/1/1/16 RESEARCH Open Access Quantification of atopy, lung function and airway hypersensitivity in adults * Susana Marinho , Angela Simpson, Paul Marsden, Jacky A Smith and Adnan Custovic Abstract Background: Studies in children have shown that concentration of specific serum IgE (sIgE) and size of skin tests to inhalant allergens better predict wheezing and reduced lung function than the information on presence or absence of atopy. However, very few studies in adults have investigated the relationship of quantitative atopy with lung function and airway hyperresponsiveness (AHR). Objective: To determine the association between lung function and AHR and quantitative atopy in a large sample of adults from the UK. Methods: FEV1 and FVC (% predicted) were measured using spirometry and airway responsiveness by methacholine challenge (5-breath dosimeter protocol) in 983 subjects (random sample of 800 parents of children enrolled in a population-based birth cohort enriched with 183 patients with physician-diagnosed asthma). Atopic status was assessed by skin prick tests (SPT) and measurement of sIgE (common inhalant allergens). We also measured indoor allergen exposure in subjects’ homes. Results: Spirometry was completed by 792 subjects and 626 underwent methacholine challenge, with 100 (16.0%) having AHR (dose-response slope25). Using sIgE as a continuous variable in a multiple linear regression analysis, we found that increasing levels of sIgE to mite, cat and dog were significantly associated with lower FEV1 (mite p = 0.001, cat p = 0.0001, dog p = 2.95 × 10-8). Similar findings were observed when using the size of wheal on skin testing as a continuous variable, with significantly poorer lung function with increa