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quantification of compensatory processes of postnatal hypoxia in newborn piglets applying short-term nonlinear dynamics analysis补偿过程的量化的产后缺氧新生儿小猪短期应用非线性动力学分析
Schulz et al. BioMedical Engineering OnLine 2011, 10:88
/content/10/1/88
RESEARCH Open Access
Quantification of compensatory processes of
postnatal hypoxia in newborn piglets applying
short-term nonlinear dynamics analysis
1 1 2 2 2 3 3
Steffen Schulz , Sina Reulecke , Michael Eiselt , Karin Schwab , Herbert Witte , Bernd Walter , Reinhard Bauer and
Andreas Voss1*
* Correspondence: voss@fh-jena.de Abstract
1Department of Medical
Engineering and Biotechnology, Background: Newborn mammals suffering from moderate hypoxia during or after
University of Applied Sciences,
Jena, Germany birth are able to compensate a transitory lack of oxygen by adapting their vital
Full list of author information is functions. Exposure to hypoxia leads to an increase in the sympathetic tone causing
available at the end of the article
cardio-respiratory response, peripheral vasoconstriction and vasodilatation in
privileged organs like the heart and brain. However, there is only limited information
available about the time and intensity changes of the underlying complex processes
controlled by the autonomic nervous system.
Methods: In this study an animal model involving seven piglets was used to
examine an induced state of circulatory redistribution caused by moderate oxygen
deficit. In addition to the main focus on the complex dynamics occurring during
sustained normocapnic hy
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