regulation of cd154-induced interleukin-12 production in synovial fluid macrophages监管cd154-induced interleukin-12生产滑液中巨噬细胞.pdfVIP

Available online /4/5/R9 Research article Regulation of CD154-induced interleukin-12 production in synovial fluid macrophages 1,2 2 3 1,2 Milja Möttönen , Pia Isomäki , Reijo Luukkainen and Olli Lassila 1Turku Graduate School of Biomedical Sciences, Turku University, Turku, Finland 2Department of Medical Microbiology, Turku University, Turku, Finland 3Satalinna Hospital, Harjavalta, Finland Corresponding author: Milja Möttönen (e-mail: milja.mottonen@utu.fi) Received: 12 March 2002 Revisions received: 20 June 2002 Accepted: 1 July 2002 Published: 26 July 2002 Arthritis Res 2002, 4:R9 © 2002 Möttönen et al., licensee BioMed Central Ltd (Print ISSN 1465-9905; Online ISSN 1465-9913) Abstract Interleukin (IL)-12, being a major cytokine that induces T helper to CD40 ligation. The expression of p40 mRNA was increased (Th) 1 differentiation and inflammatory response, has been significantly and remained upregulated after CD40 ligation, postulated to be an important mediator of synovial inflammation whereas the increase of p35 transcript expression was in rheumatoid arthritis (RA). However, the regulation of IL-12 observed only transiently and at a lower level. We further production in RA has not been elucidated. Our knowledge is observed that dendritic cells (DCs) derived in vitro from SF mainly based on studies of the production of IL-12p40 and not macrophages produced IL-12p70. Most importantly, IL-4 and the functional IL-12p70 heterodimer. We have studied the IL-13 primed SF macrophages to produce IL-12p70, whe