relation between therapeutic response and side effects induced by methylphenidate as observed by parents and teachers of children with adhd之间的关系引起的治疗反应和副作用哌醋甲酯作为家长和老师观察到的儿童多动症.pdfVIP

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relation between therapeutic response and side effects induced by methylphenidate as observed by parents and teachers of children with adhd之间的关系引起的治疗反应和副作用哌醋甲酯作为家长和老师观察到的儿童多动症.pdf

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relation between therapeutic response and side effects induced by methylphenidate as observed by parents and teachers of children with adhd之间的关系引起的治疗反应和副作用哌醋甲酯作为家长和老师观察到的儿童多动症

Lee et al. BMC Psychiatry 2011, 11:70 /1471-244X/11/70 RESEARCH ARTICLE Open Access Relation between therapeutic response and side effects induced by methylphenidate as observed by parents and teachers of children with ADHD 1 1,4 1,4 4 1,4 James Lee , Natalie Grizenko , Venkataramana Bhat , Sarojini Sengupta , Anna Polotskaia and Ridha Joober1,2,3,4* Abstract Background: The desired (therapeutic) and undesired (side) effects of methylphenidate might have underlying correlations. The aim of this study was to explore the strength and the possible sources of these correlations. Methods: One hundred and fifty-seven children with ADHD (6-12 years) were administered placebo and methylphenidate (0.5 mg/kg in a divided b.i.d. dose), each for a one-week period, in a double-blind, crossover trial. Therapeutic response was assessed using the Conners’ Global Index for parents (CGI-Parents) and teachers (CGI- Teachers), while side effects were assessed using the Barkley Side Effects Rating Scale (SERS). Results: The side effect profile as assessed by the SERS was similar to that of previous studies with insomnia, decreased appetite, and headaches showing significant treatment effects (p 0.005). These “somatic/physical” side effects did not correlate with CGI-Parents or CGI-Teachers. However, the side effects of “irritability”, “proneness to crying”, and “anxiousness” showed significant relationships with CGI-Parents. These “mood/anxiety” side effects showed no significant correlations with the CGI-Teachers. Conclusion: The greater “mood/anxiety” side effects on methylphenidate and placebo, the less the parents observe improvement of their children while treated with methylphenidate. This suggests that