原创力文档riddle reflective diffusion and local extension reveal functional associations for unannotated gene sets via proximity in a gene network谜语反射扩散和本地扩展显示功能关联未经基因集通过邻近的基因网络.pdfVIP
- 1、原创力文档（book118）网站文档一经付费（服务费），不意味着购买了该文档的版权，仅供个人/单位学习、研究之用，不得用于商业用途，未经授权，严禁复制、发行、汇编、翻译或者网络传播等，侵权必究。。
- 2、本站所有内容均由合作方或网友上传，本站不对文档的完整性、权威性及其观点立场正确性做任何保证或承诺！文档内容仅供研究参考，付费前请自行鉴别。如您付费，意味着您自己接受本站规则且自行承担风险，本站不退款、不进行额外附加服务；查看《如何避免下载的几个坑》。如果您已付费下载过本站文档，您可以点击 这里二次下载。
- 3、如文档侵犯商业秘密、侵犯著作权、侵犯人身权等，请点击“版权申诉”（推荐），也可以打举报电话：400-050-0827(电话支持时间：9:00-18:30)。
- 4、该文档为VIP文档，如果想要下载，成为VIP会员后，下载免费。
- 5、成为VIP后，下载本文档将扣除1次下载权益。下载后，不支持退款、换文档。如有疑问请联系我们。
- 6、成为VIP后，您将拥有八大权益，权益包括：VIP文档下载权益、阅读免打扰、文档格式转换、高级专利检索、专属身份标志、高级客服、多端互通、版权登记。
- 7、VIP文档为合作方或网友上传，每下载1次， 网站将根据用户上传文档的质量评分、类型等，对文档贡献者给予高额补贴、流量扶持。如果你也想贡献VIP文档。上传文档
查看更多
riddle reflective diffusion and local extension reveal functional associations for unannotated gene sets via proximity in a gene network谜语反射扩散和本地扩展显示功能关联未经基因集通过邻近的基因网络
Wang et al. Genome Biology 2012, 13:R125
/2012/13/12/R125
METHOD Open Access
RIDDLE: reflective diffusion and local extension
reveal functional associations for unannotated
gene sets via proximity in a gene network
Peggy I Wang1,2†, Sohyun Hwang3†, Rodney P Kincaid2,4, Christopher S Sullivan2,4, Insuk Lee3* and
Edward M Marcotte2,5*
Abstract
The growing availability of large-scale functional networks has promoted the development of many successful
techniques for predicting functions of genes. Here we extend these network-based principles and techniques to
functionally characterize whole sets of genes. We present RIDDLE (Reflective Diffusion and Local Extension), which
uses well developed guilt-by-association principles upon a human gene network to identify associations of gene
sets. RIDDLE is particularly adept at characterizing sets with no annotations, a major challenge where most
traditional set analyses fail. Notably, RIDDLE found microRNA-450a to be strongly implicated in ocular diseases and
development. A web application is available at /RIDDLE.
Background such as [2,3], genes are first ranked by some suitable mea-
In the modern age of high-throughput genetic studies, sure, for example, differential expression across two differ-
functional enrichment analyses remain a vital approach to ent conditions, and possible enrichment is found near the
analyzing data. Microarray, mass spectrometry, genome- extremes of the list. Rank-based methods are usually highly
wide association, and other genome-level studies com- specialized for gene expression array analysis. Both overlap
monly produce query gene sets - gene sets of interest, and rank-based methods require the querie
您可能关注的文档
- response of the human circadian system to millisecond flashes of light反应人类的生理系统毫秒闪光.pdf
- response of the diatom phaeodactylum tricornutum to photooxidative stress resulting from high light exposure响应的硅藻phaeodactylum tricornutum photooxidative压力产生的高曝光.pdf
- response of tibialis anterior tendon to a chronic exposure of stretch-shortening cycles age effects回应的胫骨前肌腱stretch-shortening周期的慢性暴露年龄的影响.pdf
- response properties of human amygdala subregions evidence based on functional mri combined with probabilistic anatomical maps响应性质的人类杏仁核条件证据基于功能磁共振成像结合概率解剖地图.pdf
- response of spinal myoclonus to a combination therapy of autogenic training and biofeedback回应的脊髓肌阵挛自生训练和生物反馈的联合治疗.pdf
- response surface methodology an emphatic tool for optimized biodiesel production using rice bran and sunflower oils响应面分析的有力工具优化使用米糠和向日葵油生产生物柴油.pdf
- response of the invasive grass imperata cylindrica to disturbance in the southeastern forests, usa响应入侵草白茅扰动的东南部森林,美国.pdf
- response surface methodology to optimize enzymatic preparation of deapio-platycodin d and platycodin d from radix platycodi响应面方法优化酶法制备桔梗的deapio-platycodin d和platycodin d.pdf
- response of the arctic pteropod limacina helicina to projected future environmental conditions北极翼足类动物的反应limacin helicina预计未来的环境条件.pdf
- response properties of the auditory telencephalon in songbirds change with recent experience and season听觉的端脑鸣鸟的属性变化的反应与最近的经验和季节.pdf
- right atrial pressure affects the interaction between lung mechanics and right ventricular function in spontaneously breathing copd patients右心房压力影响肺力学之间的交互和自发呼吸copd患者的右心室功能.pdf
- rides robust intrusion detection system for ip-based ubiquitous sensor networks骑着健壮的基于ip的无处不在的传感器网络的入侵检测系统.pdf
- right ventricular dysfunction following acute myocardial infarction in the absence of pulmonary hypertension in the mouse右心室功能障碍急性心肌梗塞后没有鼠标的肺动脉高压.pdf
- ricd a rice indica cdna database resource for rice functional genomicsricd水稻籼水稻功能基因组学的互补脱氧核糖核酸数据库资源.pdf
- right isomerism of the brain in inversus viscerum mutant mice对异构的大脑inversus viscerum突变小鼠.pdf
- rig-i is required for the inhibition of measles virus by retinoids麻疹病毒的抑制需要rig - i类维生素a.pdf
- rig-i like receptors in antiviral immunity and therapeutic applicationsrig - i受体在抗病毒免疫和治疗应用.pdf
- rigorous biogenetic network for a group of indole alkaloids derived from strictosidine严格的生物起源的网络一群来自strictosidine吲哚生物碱.pdf
- ring opening metathesis polymerization of norbornene and derivatives by the triply bonded ditungsten complex na[w2(μ-cl)3cl4(thf)2]·(thf)3开环复分解聚合norbornene和衍生品的三重保税ditungsten复杂na(w2(μ-cl)3 cl4(四氢呋喃)2]·(四氢呋喃)3.pdf
- ring cleavage reactions of methyl α-d-allopyranoside derivatives with phenylboron dichloride and triethylsilane开环反应的甲基α-d-allopyranoside衍生品与二氯化phenylboron triethylsilane.pdf
文档评论（0）