原创力文档risk adapted transmission prophylaxis to prevent vertical hiv–1 transmission effectiveness and safety of an abbreviated regimen of postnatal oral zidovudine适应传播风险预防措施以防止hiv - 1垂直传播的有效性和安全性略产后口服齐多夫定的方案.pdfVIP
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risk adapted transmission prophylaxis to prevent vertical hiv–1 transmission effectiveness and safety of an abbreviated regimen of postnatal oral zidovudine适应传播风险预防措施以防止hiv - 1垂直传播的有效性和安全性略产后口服齐多夫定的方案
Neubert et al. BMC Pregnancy and Childbirth 2013, 13:22
/1471-2393/13/22
RESEARCH ARTICLE Open Access
Risk adapted transmission prophylaxis to prevent
vertical HIV–1 transmission: Effectiveness and
safety of an abbreviated regimen of postnatal
oral Zidovudine
1* 1 1 2 3 4
Jennifer Neubert , Maren Pfeffer , Arndt Borkhardt , Tim Niehues , Ortwin Adams , Mareike Bolten ,
5 1 1
Stefan Reuter , Hans Stannigel and Hans-Juergen Laws
Abstract
Background: Antiretroviral drugs including zidovudine (ZDV) are effective in reducing HIV mother to child
transmission (MTCT), however safety concern remains. The optimal duration of postnatal ZDV has not been
established in clinical studies and there is a lack of consensus regarding optimal management. The objective of this
study was to investigate the effectiveness and safety of a risk adapted two week course of oral postnatal ZDV as
part of a combined intervention to reduce MTCT.
Methods: 118 mother infant pairs were treated according to the German-Austrian recommendations for HIV
therapy in pregnancy and in HIV exposed newborns between 2000–2010. In the absence of factors associated with
an increased HIV– 1 transmission risk, children were assigned to the low risk group and treated with an abbreviated
postnatal regimen with oral ZDV for 2 weeks. In the presence of risk factors, postnatal ZDV was escalated
accordingly.
Results: Of 118 mother-infant pairs 79 were stratified to the low risk group, 27 to the high risk group and 11 to the
very high risk group for HIV– 1 MTCT. 4 children were lost to follow up. Overall Transmission risk in the group
regardless of risk factors and completion of pr
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