role of ikknf-κb signaling in extinction of conditioned place aversion memory in ratsikknf-κb信号作用在老鼠灭绝条件性位置厌恶的记忆.pdfVIP

Role of IKK/NF-kB Signaling in Extinction of Conditioned Place Aversion Memory in Rats 1,4. 2. 1,4 3 3 3 Cheng-Hao Yang , Xiang-Ming Liu , Ji-Jian Si , Hai-Shui Shi , Yan-Xue Xue , Jian-Feng Liu , Yi- 3 3 3 4 3 3 Xiao Luo , Chen Chen , Peng Li , Jian-Li Yang *, Ping Wu *, Lin Lu 1Tianjin Medical University, Tianjin, China, 2 Department of Thoracic Oncology, Tianjin Cancer Institute and Hospital, Tianjin Medical University, Tianjin, China, 3 National Institute on Drug Dependence, Peking University, Beijing, China, 4 Tianjin Institute of Mental Health, Tianjin Mental Health Center, Tianjin, China Abstract The inhibitor kB protein kinase/nuclear factor kB (IKK/NF-kB) signaling pathway is critical for synaptic plasticity. However, the role of IKK/NF-kB in drug withdrawal-associated conditioned place aversion (CPA) memory is unknown. Here, we showed that inhibition of IKK/NF-kB by sulphasalazine (SSZ; 10 mM, i.c.v.) selectively blocked the extinction but not acquisition or expression of morphine-induced CPA in rats. The blockade of CPA extinction induced by SSZ was abolished by sodium butyrate, an inhibitor of histone deacetylase. Thus, the IKK/NF-kB signaling pathway might play a critical role in the extinction of morphine-induced CPA in rats and might be a potential pharmacotherapy target for opiate addiction. Citation: Yang C-H, Liu X-M, Si J-J, Shi H-S, Xue Y-X, et al. (2012) Role of IKK/NF-kB Signaling in Extinction of Conditioned Place Aversion Memory in Rats. PLoS ONE 7(6): e39696. doi:10.1371/journal.pone.0039696 Editor: Lisa Carlson Lyons, Florida State University, United States of America Received Fe