原创力文档safety of rituximab in the treatment of b cell malignancies implications for rheumatoid arthritis安全的利妥昔单抗治疗b细胞恶性肿瘤对类风湿性关节炎的影响.pdfVIP
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safety of rituximab in the treatment of b cell malignancies implications for rheumatoid arthritis安全的利妥昔单抗治疗b细胞恶性肿瘤对类风湿性关节炎的影响
Arthritis Research Therapy Vol 5 Suppl 4 Hainsworth
Review
Safety of rituximab in the treatment of B cell malignancies:
implications for rheumatoid arthritis
John D Hainsworth
Sarah Cannon Cancer Center, Nashville, Tennessee, USA
Correspondence: John D Hainsworth (e-mail: jhainsworth@)
Received: 29 Aug 2003 Accepted: 6 Oct 2003 Published: 2 Dec 2003
Arthritis Res Ther 2003, 5(Suppl 4):S12-S16 (DOI 10.1186/ar1008)
© 2003 BioMed Central Ltd (Print ISSN 1478-6354; Online ISSN 1478-6362)
Abstract
The chimeric anti-CD20 monoclonal antibody rituximab has been used extensively in the treatment of
B cell malignancies, and more recently it has emerged as a potential treatment for rheumatoid arthritis
(RA), via selective B lymphocyte depletion. Experience in oncology shows that rituximab is well
tolerated in a variety of settings, with mild-to-moderate infusion related reactions following the first
infusion being the most common adverse event. Current data suggest that the safety profile of
rituximab in patients with RA is similar to that in oncology, but that the adverse events are less frequent
and less severe in patients with RA.
Keywords: B cell depletion, oncology, rheumatoid arthritis, rituximab, safety
Introduction 161 patients has recently reported 24-week data that
The chimeric monoclonal antibody rituximab, which targets confirm the activity of rituximab in this indication [6]. In the
the CD20 antigen on
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