salidroside attenuates hydrogen peroxide-induced cell damage through a camp-dependent pathway红景天甙变弱氢peroxide-induced通过camp-dependent通路细胞损伤.pdfVIP

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salidroside attenuates hydrogen peroxide-induced cell damage through a camp-dependent pathway红景天甙变弱氢peroxide-induced通过camp-dependent通路细胞损伤.pdf

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salidroside attenuates hydrogen peroxide-induced cell damage through a camp-dependent pathway红景天甙变弱氢peroxide-induced通过camp-dependent通路细胞损伤

Molecules 2011, 16, 3371-3379; doi:10.3390/molecule OPEN ACCESS molecules ISSN 1420-3049 /journal/molecules Article Salidroside Attenuates Hydrogen Peroxide-Induced Cell Damage Through a cAMP-Dependent Pathway Shuang Guan 1, Wei Wang 1,†, Jing Lu 1,2,†, Wenhui Qian 2, Guoren Huang 2, Xuming Deng 1,* and Xuelin Wang 1,* 1 Institute of Zoonoses, College of Animal Science and Veterinary Medicine, Jilin University, Changchun, Jilin 130062, China; E-Mails: gshuang1973@126.com. (S.G.); wangwei@ (W.W.) 2 Laboratory of Nutrition and Function Food, Jilin University, Changchun, Jilin 130062, China; E-Mail: xlujing1@ (J.L.) † These authors contributed equally to this work. * Authors to whom correspondence should be addressed; E-Mails: xumingdeng@ (X.D.); wxlwqx@ (X.W.); Tel.: +86-431-8783-6161; Fax: +86-431-8783-6160. Received: 25 March 2011; in revised form: 8 April 2011 / Accepted: 8 April 2011 / Published: 19 April 2011 Abstract: Salidroside, a major component of Rhodiola rosea L., has shown various pharmacological functions, including antioxidant effects, but the signal transduction pathway of its antioxidant effects is not very clear. In this study, we found that salidroside could attenuate hydrogen peroxide (H O )-induced HL-7702 cell damage, inhibit 2 2 2+ 2+ H O -induced cytosolic free Ca ([Ca ]i) elevation, scavenge reactive oxygen speci