scavenger receptor class a plays a central role in mediating mortality and the development of the pro-inflammatory phenotype in polymicrobial sepsis清道夫受体a类在调解中扮演着中心角色死亡率和败血症的炎性表型幼童腹壁薄弱的发展.pdfVIP

Scavenger Receptor Class A Plays a Central Role in Mediating Mortality and the Development of the Pro- Inflammatory Phenotype in Polymicrobial Sepsis 1 1 2 2 3 Tammy R. Ozment *, Tuanzhu Ha , Kevin F. Breuel , Tiffany R. Ford , Donald A. Ferguson , 4 5 6 1 1 John Kalbfleisch , John B. Schweitzer , Jim L. Kelley , Chuanfu Li , David L. Williams 1 Department of Surgery, East Tennessee State University, Quillen College of Medicine, Johnson City, Tennessee, United States of America, 2 Department of Obstetrics and Gynecology, East Tennessee State University, Quillen College of Medicine, Johnson City, Tennessee, United States of America, 3 Department of Biomedical Sciences, East Tennessee State University, Quillen College of Medicine, Johnson City, Tennessee, United States of America, 4 Department of Medical Education, East Tennessee State University, Quillen College of Medicine, Johnson City, Tennessee, United States of America, 5 Department of Pathology, East Tennessee State University, Quillen College of Medicine, Johnson City, Tennessee, United States of America, 6 Department of Internal Medicine, East Tennessee State University, Quillen College of Medicine, Johnson City, Tennessee, United States of America Abstract Sepsis is a frequent complication in critical illness. The mechanisms that are involved in initiation and propagation of the disease are not well understood. Scavenger receptor A (SRA) is a membrane receptor that binds multiple polyanions such as oxidized LDL and endotoxin. Recent studies suggest that SRA acts as a pattern recognition receptor in the innate immune response. The goal of the present study was to determine the role of SRA in polymicrobial s