原创力文档self-assembled hydrogel nanoparticles for drug delivery applications自组装水凝胶纳米粒子药物交付应用程序.pdfVIP
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self-assembled hydrogel nanoparticles for drug delivery applications自组装水凝胶纳米粒子药物交付应用程序
Materials 2010, 3, 1420-1460; doi:10.3390/ma3021420
OPEN ACCESS
materials
ISSN 1996-1944
/journal/materials
Review
Self-Assembled Hydrogel Nanoparticles for Drug Delivery
Applications
Catarina Gonçalves, Paula Pereira and Miguel Gama *
IBB-Institute for Biotechnology and Bioengineering, Centre for Biological Engineering, Minho
University, Campus de Gualtar 4710-057, Braga, Portugal;
E-Mails: cgoncalves@deb.uminho.pt (C.G.); paulapereira@deb.uminho.pt (P.P.)
* Author to whom correspondence should be addressed; E-Mail: fmgama@deb.uminho.pt;
Tel.: +351 253 604 400; Fax: +351 253 678 986.
Received: 13 January 2010; in revised form: 4 February 2010 / Accepted: 21 February 2010 /
Published: 24 February 2010
Abstract: Hydrogel nanoparticles—also referred to as polymeric nanogels or
macromolecular micelles—are emerging as promising drug carriers for therapeutic
applications. These nanostructures hold versatility and properties suitable for the delivery
of bioactive molecules, namely of biopharmaceuticals. This article reviews the latest
developments in the use of self-assembled polymeric nanogels for drug delivery
applications, including small molecular weight drugs, proteins, peptides, oligosaccharides,
vaccines and nucleic acids. The materials and techniques used in the development of
self-assembling nanogels are also described.
Keywords: polymer; delivery; targeting; self-assembly; drugs
1. Introduction
Nanote
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