symptoms induced by environmental irritants and health-related quality of life in patients with chronic cough - a cross-sectional study环境刺激引起的症状和慢性咳嗽患者健康相关的生活质量u2014u2014一个横断面研究.pdfVIP

Ternesten-Hasséus et al. Cough 2011, 7:6 /content/7/1/6 Cough RESEARCH Open Access Symptoms induced by environmental irritants and health-related quality of life in patients with chronic cough - A cross-sectional study Ewa Ternesten-Hasséus1*, Sven Larsson2 and Eva Millqvist1 Abstract Background: Chronic cough is a common condition, but some patients have no evident medical explanation for their symptoms. A group of patients has been identified, characterized by upper and lower airway symptoms triggered by chemicals and scents, and heightened cough sensitivity to inhaled capsaicin. Chronic cough is usually a prominent symptom in these patients, and it has been suggested that they suffer from sensory hyperreactivity. Our main aim was to analyse, in a group of patients with chronic cough, the presence of symptoms induced by environmental factors such as chemicals, scents, and cold air, and to measure the social and emotional influences of these symptoms in relation to quality of life. A second aim was to pilot-test a Swedish translation of a cough- specific questionnaire. Methods: A total of 119 patients with chronic cough were asked to answer three different questionnaires: a local symptom questionnaire, the Chemical Sensitivity Scale for Sensory Hyperreactivity (CSS-SHR), and the Nottingham Health Profile (NHP). In addition, a Swedish version of the Hull Airway Reflux Questionnaire (HARQ) was developed and answered by a subgroup of patients and healthy controls. Results: Sixty-two patients (52%) with mean cough duration of 10.6 years answered the local symptom questionnaire, the CSS-SHR, and the NHP. Of these, 39 (63%) claimed to have cough and other symptoms induced by chemicals and scents. Compared to population-based find