terpenoids from cleome droserifolia (forssk.) del萜类化合物从醉蝶花属droserifolia(forssk)。.pdfVIP

Molecules 2005, 10, 971–977 molecules ISSN 1420-3049 Terpenoids from Cleome droserifolia (Forssk.) Del. Hesham I. El-Askary Pharmacognosy Department, Faculty of Pharmacy, Cairo University, 11562 Cairo, Egypt; e-mail heshamaskary@ Received: 23 January 2005; in revised form: 15 April 2005 / Accepted: 17 April 2005 / Published: 31 August 2005 Abstract: A new diacetyl triterpene lactone, drosericarpone (2), was isolated from the hexane extract of the herb Cleome droserifolia, together with buchariol (1, a sesquiterpene oxide, isolated for the first time from Cleome species) and stigmasterol glucoside (3). The structures of 1-3 were identified by spectroscopic means. Keywords: Cleome droserifolia, Cleomaceae, buchariol, drosericarpone INTRODUCTION Cleome droserifolia (Forssk.) Del. belongs to Family Cleomaceae [1,2]. Cleome species are generally used in folk medicine as stomachics, rubefacients and in the treatment of scabies, rheumatic fever and inflammation [3-6]. The dried herb of C. droserifolia, locally known as Samwah, Afein, Reeh-El-Bard [7], is used by herbalists in Egypt as a hypoglycemic agent, and its decoction is widely used by the Bedouins of the southern Sinai for the treatment of diabetes [8]. Several studies were carried out to confirm the hypoglycemic effect of the decoction of this herb [8-10]. Flavonoids [7,11-15] and sesquiterpenes (carotol and an unidentified one) were isolated from C. droserifolia [22]. To date, several dammarane triterpenes h