the antioxidant activity of new coumarin derivatives新的香豆素衍生物的抗氧化活性.pdfVIP

Int. J. Mol. Sci. 2011, 12, 5747-5761; doi:10.3390/ijm OPEN ACCESS International Journal of Molecular Sciences ISSN 1422-0067 /journal/ijms Article The Antioxidant Activity of New Coumarin Derivatives Abdul Amir H. Kadhum 1, Ahmed A. Al-Amiery 1,2,*, Ahmed Y. Musa 1 and Abu Bakar Mohamad 1 1 Department of Chemical and Process Engineering, Faculty of Engineering and Built Environment, Universiti Kebangsaan Malaysia, Bangi, Selangor 43600, Malaysia; E-Mails: amir@eng.ukm.my (A.A.H.K.); ahmedym@eng.ukm.my (A.Y.M.); drab@eng.ukm.my(A.B.M.) 2 Biotechnology Division, Applied Science Department, University of Technology, Baghdad 10066, Iraq * Author to whom the correspondence should be addressed; E-Mail: dr.ahmed@eng.ukm.my, or dr.ahmed1975@; Tel.: 0061-9290-3670. Received: 12 July 2011; in revised form: 18 August 2011 / Accepted: 22 August 2011 / Published: 7 September 2011 Abstract: The antioxidant activity of two synthesized coumarins namely, N-(4,7-dioxo-2- phenyl-1,3-oxazepin-3(2H,4H,7H)-yl)-2-(2-oxo-2H-chromen-4-yloxy)acetamide 5 and N-(4-oxo-2-phenylthiazolidin-3-yl)-2-(2-oxo-2H-chromen-4-yloxy)acetamide 6 were studied with the DPPH, hydrogen peroxide and nitric oxide radical methods and compared with the known antioxidant ascorbic acid. Compounds 5 and 6 were synthesized in a good yield from the addition reaction of maleic anhydride or mercaptoacetic acid to compound 4 ， namely N-benzylidene-2-(2-oxo-2H-chromen-4-yloxy