the anti-sigma factor tcdc modulates hypervirulence in an epidemic binap1027 clinical isolate of clostridium difficileanti-sigma因素tcdc调节hypervirulence在流行病binap1027临床梭状芽胞杆菌的分离.pdfVIP
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the anti-sigma factor tcdc modulates hypervirulence in an epidemic binap1027 clinical isolate of clostridium difficileanti-sigma因素tcdc调节hypervirulence在流行病binap1027临床梭状芽胞杆菌的分离
The Anti-Sigma Factor TcdC Modulates Hypervirulence in
an Epidemic BI/NAP1/027 Clinical Isolate of Clostridium
difficile
1 2 3 1 1
Glen P. Carter , Gillian R. Douce , Revathi Govind , Pauline M. Howarth , Kate E. Mackin , Janice
2 2 4 5 5 4
Spencer , Anthony M. Buckley , Ana Antunes , Despina Kotsanas , Grant A. Jenkin , Bruno Dupuy ,
1 1
Julian I. Rood , Dena Lyras *
1 Department of Microbiology, Monash University, Clayton, Victoria, Australia, 2 Division of Infection and Immunity, FBLS Glasgow Biomedical Research Centre, University
`
of Glasgow, Glasgow, United Kingdom, 3 Division of Biology, Kansas State University, Manhattan, Kansas, United States of America, 4 Laboratoire Pathogenese des
´ ´
Bacteries Anaerobies, Institut Pasteur, Paris, France, 5 Department of Infectious Diseases, Southern Health, Monash Medical Centre, Clayton, Victoria, Australia
Abstract
Nosocomial infections are increasingly being recognised as a major patient safety issue. The modern hospital environment
and associated health care practices have provided a niche for the rapid evolution of microbial pathogens that are well
adapted to surviving and proliferating in this setting, after which they can infect susceptible patients. This is clearly the case
for bacterial pathogens such as Methicillin Resistant Staphylococcus aureus (MRSA) and Vancomycin Resistant Enterococcus
(VRE) species, both of which have acquired resistanc
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