原创力文档the effect of antiretroviral combination treatment on epstein-barr virus (ebv) genome load in hiv-infected patients抗逆转录病毒联合治疗的效果在eb病毒(ebv)感染艾滋病毒的患者的基因组负载.pdfVIP
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the effect of antiretroviral combination treatment on epstein-barr virus (ebv) genome load in hiv-infected patients抗逆转录病毒联合治疗的效果在eb病毒(ebv)感染艾滋病毒的患者的基因组负载
Viruses 2010, 2, 867-879; doi:10.3390/v2040867
OPEN ACCESS
viruses
ISSN 1999-4915
/journal/viruses
Article
The Effect of Antiretroviral Combination Treatment on
Epstein-Barr Virus (EBV) Genome Load in HIV-Infected
Patients
Anna M. C. Friis 1, Katarina Gyllensten 2, Anna Aleman 1, Ingemar Ernberg 1,* and
Börje Åkerlund 3
1 Microbiology and Tumor Biology Center, Karolinska Institute, SE-171 65 Stockholm, Sweden;
E-Mails: anna.friis@ki.se (A.M.C.F.); anna.aleman@ki.se (A.A.)
2 Gay Men’s Health Clinic, Karolinska Institutet, Department of Clinical Science and Education,
Södersjukhuset, SE-118 83 Stockholm, Sweden;
E-Mail: katarina.gyllensten@sodersjukhuset.se (K.G.)
3 Department of Infectious Diseases, Karolinska University Hospital, Huddinge, SE-141 86
Stockholm, Sweden; E-Mail: borje.akerlund@karolinska.se (B.Å.)
* Author to whom correspondence should be addressed; E-Mail: ingemar.ernberg@ki.se;
Tel.: +46 8 5248 6262; Fax: +46 8 31 94 70.
Received: 2 December 2009; in revised form: 24 February 2010 / Accepted: 2 March 2010 /
Published: 29 March 2010
Abstract: We evaluated the effect of combination anti-retroviral treatment (cART) on the
host control of EBV infection in moderately immunosuppressed HIV-1 patients. Twenty
HIV-1 infected individuals were followed for five years with repeated measurements of
EBV DNA load in peripheral blood lymphocytes in relation to HIV-RNA titers and CD4+
cell counts. Individuals with optimal response, i.e. durable non-detectable HIV-RNA,
showed a decline of
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