原创力文档the effect of cinnamaldehyde on mucositis and salivary antioxidant capacity in gamma-irradiated rats (a preliminary study)肉桂醛的影响在粘膜炎和唾液gamma-irradiated大鼠抗氧化能力(初步研究).pdfVIP
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the effect of cinnamaldehyde on mucositis and salivary antioxidant capacity in gamma-irradiated rats (a preliminary study)肉桂醛的影响在粘膜炎和唾液gamma-irradiated大鼠抗氧化能力(初步研究)
Molania et al. DARU Journal of Pharmaceutical Sciences 2012, 20:89
/content/20/1/89
RESEARCH ARTICLE Open Access
The effect of Cinnamaldehyde on mucositis and
salivary antioxidant capacity in gamma-irradiated
rats (a preliminary study)
1 2 3 4 5 4
Tahereh Molania , Ali Akbar Moghadamnia , Mahdi Pouramir , Sara Aghel , Dariush Moslemi , Leila Ghassemi
and Mina Motallebnejad4,6*
Abstract
Background and purpose of the study: The aim of this study was to investigate the effect of cinnamaldehyde on
mucositis and salivary total antioxidant capacity in gamma-irradiated rats.
Methods: The study was conducted on 28 male Wistar rats, 7– 11 weeks of age and 160 ± 20 g body weight,
divided into four groups of seven rats each. The first group receiving normal saline (S), the second group receiving
saline and gamma radiation (SR), the third group receiving 50 mg/kg cinnamaldehyde 98% (C), and the fourth
group receiving 50 mg/kg cinnamaldehyde 98% and gamma radiation (CR). SR and CR groups were exposed to
15 Gy gamma irradiation for 7 min and 39 s. Rats were intraperitoneally injected each day during the 10-day period
of the experiment, and their tongues and lips were examined to assess the incidence and severity of mucositis. The
saliva samples were taken from the animals three times on day zero, six, and ten.
Results: The mean mucositis incidence appeared to be delayed in the CR than the SR group (P = 0.024), and the
severity was significantly higher in the SR compared to the CR group;the difference was statistically significant on
the second day (P = 0.027). In the evaluation of salivary antioxidant capacity, salivary antioxidant concentration was
significantly higher in the C than the S, SR, and CR
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