原创力文档the effect of glutamine infusion on the inflammatory response and hsp70 during human experimental endotoxaemia谷氨酰胺的影响灌注在炎症反应和hsp70在人类实验endotoxaemia.pdfVIP
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the effect of glutamine infusion on the inflammatory response and hsp70 during human experimental endotoxaemia谷氨酰胺的影响灌注在炎症反应和hsp70在人类实验endotoxaemia
Available online /content/13/1/R7
Vol 13 No 1 Open Access
Research
The effect of glutamine infusion on the inflammatory response
and HSP70 during human experimental endotoxaemia
1 1 1
Anne Sofie Andreasen *, Theis Pedersen-Skovsgaard *, Ole Hartvig Mortensen *, Gerrit van
1,2 1 1
Hall , Pope Lloyd Moseley and Bente Klarlund Pedersen
1The Centre of Inflammation and Metabolism, Department of Infectious Diseases and Copenhagen Muscle Research Center, Rigshospitalet, Faculty
of Health Sciences, University of Copenhagen, Blegdamsvej, DK-2100 Copenhagen, Denmark
2Department of Biomedical Sciences, University of Copenhagen, Tagensvej, DK-2200 Copenhagen, Denmark
* Contributed equally
Corresponding author: Anne Sofie Andreasen, sofie_andreasen@
Received: 29 Oct 2008 Revisions requested: 6 Dec 2008 Revisions received: 19 Dec 2008 Accepted: 27 Jan 2009 Published: 27 Jan 2009
Critical Care 2009, 13:R7 (doi:10.1186/cc7696)
This article is online at: /content/13/1/R7
© 2009 Andreasen et al.; licensee BioMed Central Ltd.
This is an open access article distributed under the terms of the Creative Commons Attribution License (/licenses/by/2.0),
which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract
Introduction Glutamine supplementation has beneficial effects Results Plasma glutamine increased during alanine-glutamine
on morbidity and mortality in critically ill patients, possibly in part infusion. Endotoxin reduced plasma glutamine during both trials,
through an attenuation of the proinflammatory c
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