原创力文档the effect of halothane and pentobarbital sodium on brain ependymal cilia氟烷和戊巴比妥钠的影响大脑室管膜纤毛.pdfVIP
- 1、原创力文档（book118）网站文档一经付费（服务费），不意味着购买了该文档的版权，仅供个人/单位学习、研究之用，不得用于商业用途，未经授权，严禁复制、发行、汇编、翻译或者网络传播等，侵权必究。。
- 2、本站所有内容均由合作方或网友上传，本站不对文档的完整性、权威性及其观点立场正确性做任何保证或承诺！文档内容仅供研究参考，付费前请自行鉴别。如您付费，意味着您自己接受本站规则且自行承担风险，本站不退款、不进行额外附加服务；查看《如何避免下载的几个坑》。如果您已付费下载过本站文档，您可以点击 这里二次下载。
- 3、如文档侵犯商业秘密、侵犯著作权、侵犯人身权等，请点击“版权申诉”（推荐），也可以打举报电话：400-050-0827(电话支持时间：9:00-18:30)。
- 4、该文档为VIP文档，如果想要下载，成为VIP会员后，下载免费。
- 5、成为VIP后，下载本文档将扣除1次下载权益。下载后，不支持退款、换文档。如有疑问请联系我们。
- 6、成为VIP后，您将拥有八大权益，权益包括：VIP文档下载权益、阅读免打扰、文档格式转换、高级专利检索、专属身份标志、高级客服、多端互通、版权登记。
- 7、VIP文档为合作方或网友上传，每下载1次， 网站将根据用户上传文档的质量评分、类型等，对文档贡献者给予高额补贴、流量扶持。如果你也想贡献VIP文档。上传文档
查看更多
the effect of halothane and pentobarbital sodium on brain ependymal cilia氟烷和戊巴比妥钠的影响大脑室管膜纤毛
O’Callaghan and Sikand Cilia 2012, 1:12
/content/1/1/12
RESEARCH Open Access
The effect of halothane and pentobarbital sodium
on brain ependymal cilia
Chris O’Callaghan2* and Kulvinder Sikand1
Abstract
Background: The effect of anesthetic agents on ependymal ciliary function is unknown. The aim of this study was
to determine the effect of halothane and pentobarbital sodium on brain ependymal ciliary function.
Methods: We used an ex vivo rat brain slice model to measure ependymal ciliary beat frequency by high speed
video photography at 37°C.
Results: Exposure to halothane caused a significant reduction in ciliary beat frequency of 2 % (P = 0.006), 15.5 %
(P 0.001), and 21.5 % (P 0.001) for halothane concentrations of 1.8 %, 3.4 % and 4.4 %, respectively, compared to
controls. Following a one-hour wash-out period, there was no significant difference between control samples and
cilia that had been exposed to 1.8 % (P = 0.5) and 3.4 % (P = 0.3) halothane. The beat frequency of cilia exposed to
4.4 % halothane had increased following the wash-out period but cilia were still beating significantly more slowly
than cilia from the control group (P = 0.001).
Pentobarbitone at concentrations of 25 and 50 μg/ml had no effect on ciliary beat frequency compared to controls
(P = 0.6 and 0.4 respectively). A significant (P = 0.002) decrease in ciliary beat frequency was seen following
incubation with a pentobarbitone concentration of 250 μg/ml (mean (SD) frequency, 24(8) Hz compared to
controls, 38(9) Hz).
Conclusions: Halothane reversibly inhibits the rate at which ependymal cilia beat. Pentobarbitone has no effect on
ciliary activity at levels used for anesthesia. It is unclear whether the slowing of ependymal ciliary by halothane is
responsible for some of the secondary central nervous system effects of
您可能关注的文档
- the critical role of arginine residues in the binding of human monoclonal antibodies to cardiolipin精氨酸残基的至关重要的作用在人类单克隆抗体的结合心磷脂.pdf
- the crf domain defines cytokinin response factor proteins in plantscrf域定义了细胞分裂素在植物响应因子的蛋白质.pdf
- the critical role of il-34 in osteoclastogenesis在osteoclastogenesis il-34的至关重要的作用.pdf
- the critical role of partially exposed n-terminal valine residue in stabilizing gh10 xylanase from bacillus sp.ng-27 under poly-extreme conditions部分暴露的氨基端缬氨酸残基的关键作用在稳定gh10木聚糖酶的芽孢杆菌sp.ng-27 poly-extreme条件下.pdf
- the critical role of notch ligand delta-like 1 in the pathogenesis of influenza a virus (h1n1) infection切口配体delta-like 1的关键作用的甲型流感病毒(h1n1)感染的发病机理.pdf
- the critically-ill pediatric hemato-oncology patient epidemiology, management, and strategy of transfer to the pediatric intensive care unit小儿hemato-oncology重病患者流行病学、管理和战略转移的儿科重症监护室.pdf
- the cross-sectional gras sample a comprehensive phenotypical data collection of schizophrenic patients横断面肝样品全面的精神分裂症患者的表型数据收集.pdf
- the crosstalk of ptgs2 and egf signaling pathways in colorectal cancerptgs2相声和表皮生长因子信号通路在结肠直肠癌.pdf
- the critical role of n- and c-terminal contact in protein stability and folding of a family 10 xylanase under extreme conditionsn - c端接触的关键作用蛋白质稳定性和折叠的家庭10在极端条件下木聚糖酶.pdf
- the criteria to confirm the role of epstein-barr virus in nasopharyngeal carcinoma initiation标准确认巴尔病毒在鼻咽癌启蒙的作用.pdf
- the effect of group size on the interplay between dominance and reproduction in bombus terrestris集团规模优势之间的相互作用的影响和繁殖bombus terrestris.pdf
- the effect of handwashing with water or soap on bacterial contamination of hands的影响与水或肥皂洗手手的细菌污染.pdf
- the effect of high ambient temperature on the elderly population in three regions of sweden高环境温度的影响在三个地区老年人口的瑞典.pdf
- the effect of hatchery release strategy on marine migratory behaviour and apparent survival of seymour river steelhead smolts (oncorhynchus mykiss)孵卵所释放的影响策略对海洋迁徙行为和明显的生存西摩河虹鳟溯河洄游雄mykiss).pdf
- the effect of high-altitude on human skeletal muscle energetics 31p-mrs results from the caudwell xtreme everest expedition高海拔的影响对人类骨骼肌能量31 p-mrs考德威尔严酷的喜马拉雅探险的结果.pdf
- the effect of hypertensive disorders in pregnancy on small for gestational age and stillbirth a population based study妊娠高血压的影响在小胎龄和死胎基于人口的研究.pdf
- the effect of immunomodulators on the immunogenicity of tnf-blocking therapeutic monoclonal antibodies a review的效果免疫调制剂对肿瘤坏死因子抑制剂中治疗性单克隆抗体的免疫原性审查.pdf
- the effect of health facility delivery on neonatal mortality systematic review and meta-analysis卫生设施交付在新生儿死亡率的影响的系统回顾和荟萃分析.pdf
- the effect of improved rural sanitation on diarrhoea and helminth infection design of a cluster-randomized trial in orissa, india改善农村环境卫生的影响在腹泻和寄生虫感染集群随机试验设计在奥里萨邦,印度.pdf
- the effect of inappropriate calibration three case studies in molecular ecology不恰当的校准的影响三个案例研究在分子生态学.pdf
文档评论（0）