the effects of dopamine and epinephrine on hemodynamics and oxygen metabolism in hypoxic anesthetized piglets多巴胺和肾上腺素的影响在缺氧的血液动力学和氧代谢麻醉小猪.pdfVIP

Available online /content/5/3/158 Primary research The effects of dopamine and epinephrine on hemodynamics and oxygen metabolism in hypoxic anesthetized piglets * † Po-Yin Cheung and Keith J Barrington *University of Alberta, Edmonton, Alberta, Canada †McGill University, Montreal, Quebec, Canada Correspondence: KJ Barrington, MBChB, FRCP(C), MRCP(UK), Room C7.68, Royal Victoria Hospital, 687 Pine Ave W, Montreal, Quebec, Canada H3A 1A1. Tel: 514 842 1231 (ext 4876); fax: 514 843 1741; e-mail: kbarri@po-box.mcgill.ca Received: 10 November 2000 Critical Care 2001, 5:158–166 Revisions requested: 14 December 2000 This article may contain supplementary data which can only be found Revisions received: 28 February 2001 online at /content/5/3/158 Accepted: 12 April 2001 © 2001 Cheung and Barrington et al, licensee BioMed Central Ltd Published: 26 April 2001 (Print ISSN 1364-8535; Online ISSN 1466-609X) Abstract Background: The most appropriate inotropic agent for use in the newborn is uncertain. Dopamine and epinephrine are commonly used, but have unknown effects during hypoxia and pulmonary hypertension; the effects on the splanchnic circulation, in particular, are unclear. Methods: The effects on the systemic, pulmonary, hepatic, and mesenteric circulations of infusions of dopamine and epinephrine (adrenaline) were compared in 17 newborn piglets. Three groups [control (n = 5), dopamine (n = 6) and epinephrine (n = 6)] of fentanyl anesthetized newborn piglets