原创力文档the effects of depression and use of antidepressive medicines during pregnancy on the methylation status of the igf2 imprinted control regions in the offspring抑郁的影响,在怀孕期间使用抗抑郁的药物igf2印迹控制区域的甲基化状态的后代.pdfVIP
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the effects of depression and use of antidepressive medicines during pregnancy on the methylation status of the igf2 imprinted control regions in the offspring抑郁的影响,在怀孕期间使用抗抑郁的药物igf2印迹控制区域的甲基化状态的后代
Soubry et al. Clinical Epigenetics 2011, 3:2
/content/3/1/2
RESEARCH Open Access
The effects of depression and use of
antidepressive medicines during pregnancy on
the methylation status of the IGF2 imprinted
control regions in the offspring
1 2 2 2 1,3 4 1 5
A Soubry , SK Murphy , Z Huang , A Murtha , JM Schildkraut , RL Jirtle , F Wang , J Kurtzberg ,
W Demark-Wahnefried6, MR Forman7 and C Hoyo1,3*
Abstract
In utero exposures to environmental factors may result in persistent epigenetic modifications affecting normal
development and susceptibility to chronic diseases in later life. We explored the relationship between exposure of
the growing fetus to maternal depression or antidepressants and DNA methylation at two differentially methylated
regions (DMRs) of the imprinted Insulin-like Growth Factor 2 (IGF2) gene. Aberrant DNA methylation at the IGF2 and
neighboring H19 DMRs has been associated with deregulated IGF2 expression, childhood cancers and several
chronic diseases during adulthood. Our study population is comprised of pregnant mothers and their newborns (n
= 436), as part of the Newborn Epigenetics Study (NEST). A standardized questionnaire was completed and
medical record data were abstracted to ascertain maternal depression and antidepressive drug use. DMR
methylation levels in umbilical cord blood leukocytes were quantified using pyrosequencing. From the 436
newborns, laboratory data were obtained for 356 individuals at the IGF2 DMRs, and for 411 individuals at the H19
DMRs; about half of each group was African American or Caucasian. While overall no association between
depression and methylation profiles was found, we observed a significant hypermethylation of the H19 DMRs in
new
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