原创力文档the electrically silent kv6.4 subunit confers hyperpolarized gating charge movement in kv2.1kv6.4 heterotetrameric channels电沉默kv6.4单元赋予超极化控制电荷运动kv2.1kv6.4 heterotetrameric频道.pdfVIP
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the electrically silent kv6.4 subunit confers hyperpolarized gating charge movement in kv2.1kv6.4 heterotetrameric channels电沉默kv6.4单元赋予超极化控制电荷运动kv2.1kv6.4 heterotetrameric频道
The Electrically Silent Kv6.4 Subunit Confers
Hyperpolarized Gating Charge Movement in Kv2.1/Kv6.4
Heterotetrameric Channels
1,2 1 1 2
Elke Bocksteins , Alain J. Labro , Dirk J. Snyders *, Durga P. Mohapatra *
1 Laboratory for Molecular Biophysics, Physiology and Pharmacology, Department of Biomedical Sciences, University of Antwerp, CDE, Universiteitsplein 1, Antwerpen,
Belgium, 2 Department of Pharmacology, The University of Iowa Roy J. and Lucile A. Carver College of Medicine, Iowa City, Iowa, United States of America
Abstract
The voltage-gated K+ (Kv) channel subunit Kv6.4 does not form functional homotetrameric channels but co-assembles with
Kv2.1 to form functional Kv2.1/Kv6.4 heterotetrameric channels. Compared to Kv2.1 homotetramers, Kv6.4 exerts a ,40 mV
hyperpolarizing shift in the voltage-dependence of Kv2.1/Kv6.4 channel inactivation, without a significant effect on
activation gating. However, the underlying mechanism of this Kv6.4-induced modulation of Kv2.1 channel inactivation, and
whether the Kv6.4 subunit participates in the voltage-dependent gating of heterotetrameric channels is not well
understood. Here we report distinct gating charge movement of Kv2.1/Kv6.4 heterotetrameric channels, compared to Kv2.1
homotetramers, as revealed by gating current recordings from mammalian cells expressing these channels. The gating
charge movement of Kv2.1/Kv6.4 heterotetrameric channels displayed an extra component around the physiological K+
equilibrium potential, characterized by a second sigmoidal relationship of the voltage-dependence of gating charge
movement. This distinct gating charge displacement reflects movement of
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