原创力文档what do effective treatments for multiple sclerosis tell us about the molecular mechanisms involved in pathogenesis有效治疗多发性硬化症告诉了我们参与发病的分子机制呢.pdfVIP
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what do effective treatments for multiple sclerosis tell us about the molecular mechanisms involved in pathogenesis有效治疗多发性硬化症告诉了我们参与发病的分子机制呢
Int. J. Mol. Sci. 2012, 13, 12665-12709; doi:10.3390/ijms131012665
OPEN ACCESS
International Journal of
Molecular Sciences
ISSN 1422-0067
/journal/ijms
Review
What Do Effective Treatments for Multiple Sclerosis Tell Us
about the Molecular Mechanisms Involved in Pathogenesis?
Katherine A. Buzzard 1,*, Simon A. Broadley 2,3 and Helmut Butzkueven 4
1 Department of Neurology, Royal Melbourne Hospital, Royal Parade, Parkville VIC 3050, Australia
2 School of Medicine, Griffith University, Gold Coast Campus, QLD 4222, Australia;
E-Mail: simon.broadley@.au
3 Department of Neurology, Gold Coast Hospital, 108 Nerang Street, Southport QLD 4215, Australia
4 Melbourne Brain Centre at the Royal Melbourne Hospital, Department of Medicine,
University of Melbourne, Royal Parade, Parkville VIC 3010, Australia;
E-Mail: butz@.au
* Author to whom correspondence should be addressed; E-Mail: kabuzzard@;
Tel.: +61-3-8344-1802; Fax: +61-3-9348-1707.
Received: 2 August 2012; in revised form: 8 September 2012 / Accepted: 12 September 2012 /
Published: 4 October 2012
Abstract: Multiple sclerosis is a potentially debilitating disease of the central nervous
system. A concerted program of research by many centers around the world has
consistently demonstrated the importance of the immune system in its pathogenesis. This
knowledge has led to the formal testing of a number of therapeutic agents in both animal
models and humans. These c
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