儿童社区获得性肺炎继发腹泻相关因素分析及微生态制剂预防作用.docVIP

儿童社区获得性肺炎继发腹泻相关因素分析及微生态制剂预防作用 　【摘要】 　　目的 探讨小儿肺炎继发腹泻的危险因素及应用微生态制剂预防的效果。方法 调查2007年1月至2009年1月在蒲江县人民医院和成都市儿童专科医院住院治疗的儿童社区获得性肺炎362例，以住院期间抗生素治疗同时应用微生态制剂的患儿为病例组，仅使用抗生素治疗或住院72 h后因出现继发腹泻才开始应用微生态制剂的患儿为对照组,对肺炎患儿的临床特征、微生态制剂的应用情况与继发腹泻的关系进行单因素卡方分析和非条件Logistic回归模型多因素分析。结果 病例组152例,住院治疗期间继发腹泻病16例,发生率为11%;对照组201例，继发腹泻61例,发生率30%。单因素χ2分析显示:患儿发病年龄、住院天数、微生态制剂的应用、居住地、病情严重程度、是否合并其他疾病、血中性粒细胞比例、特应性、激素和中成药制剂应用与儿童社区获得性肺炎继发腹泻有关联。非条件Logistic多因素回归分析筛选出4个危险因素,即患儿年龄、住院天数、病情严重程度、特应性和1个保护因素:微生态制剂应用。结论 社区获得性肺炎患儿年龄越小、住院时间越长、病情严重和儿童具特应性有可增加继发腹泻的发生率;微生态制剂能够降低小儿肺炎继发腹泻的发生率,提示具有预防作用。 【关键词】 肺炎 腹泻 危险因素 微生态制剂 儿童 　　[Abstract] Objective To investigate the community-acquired and diarrhea in children on the risk factors and its application to prevent the effects of probiotics.Methods Investigated from January 2007 to January 2009 in Pujiang County,the treatment of children hospitalized with community-acquired pneumonia in 362 cases,antibiotic treatment during hospitalization in the application of probiotics at the same time as the cases of children with groups,only used antibiotics or after 72 h of hospital treatment diarrhea occurred before applications to start to use probiotics in children as a control group with clinical features of community-acquired pneumonia.Analysis of variance (ANOVA) study and nonconditional multiplicity logistic regression model analysis were used to analyze the relationships between the clinical features of children with community-acquired pneumonia,the use of Bifico and diarrhea in children with community-acquired pneumonia.The data were analyzed by SPSS(Version 10.0).Results In 152 cases of patients,had the secondary treatment 16 cases of diarrheal diseases,the incidence rate was 11%;in 201 cases of the control group,61 cases were secondary diarrhea,the incidence was 30%.ANOVA indicated:age,hospitalization day,the application of probiotics,the proportion of blood neutrophils,atopic,hormone application,residence place,severity of illness,whether or not with other disease,blood granul