evaluation of the effect of systolic blood pressure and pulse pressure on cognitive function the womens health and aging study ii评价收缩压和脉压的影响认知功能的妇女的健康和衰老研究ii.pdfVIP

Evaluation of the Effect of Systolic Blood Pressure and Pulse Pressure on Cognitive Function: The Women’s Health and Aging Study II 1,2 3 4 2,5 2,3 Sevil Yasar *, Jean Y. Ko , Stephanie Nothelle , Michelle M. Mielke , Michelle C. Carlson 1 Division of Geriatric Medicine and Gerontology, Department of Medicine, Johns Hopkins School of Medicine, Baltimore, Maryland, United States of America, 2 Center on Aging and Health, Johns Hopkins School of Medicine, Baltimore, Maryland, United States of America, 3 Department of Mental Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, United States of America, 4 Indiana University School of Medicine, Indianapolis, Indiana, United States of America, 5 Division of Epidemiology, Mayo Clinic, Rochester, Minnesota, United States of America Abstract Background: Evidence suggests that elevated systolic blood pressure (SBP) and pulse pressure (PP) in midlife is associated with increased risk for cognitive impairment later in life. There is mixed evidence regarding the effects of late life elevated SBP or PP on cognitive function, and limited information on the role of female gender. Methods/Principal Findings: Effects of SBPand PPon cognitive abilities at baseline and over a 9-year period were evaluated in 337 non-demented community-dwelling female participants over age 70 in the Women’s Health and Aging Study II using logistic and Cox proportional hazards regression analyses. Participants aged 76–80 years with SBP$160 mmHg or PP$84 mmHg showed increased incidence of impairment on Trail Making Test-Part B (TMT, Part B), a measure of executive function, over time when compared to the control group that included pa