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the role of leptin in innate and adaptive immune responses瘦素在先天和适应性免疫反应的作用
Available online /content/8/5/217
Review
The role of leptin in innate and adaptive immune responses
1 2,3 2,3
Eiva Bernotiene , Gaby Palmer and Cem Gabay
1Department of Experimental Research, Institute of Experimental and Clinical Medicine, Vilnius University, Vilnius, Lithuania
2Division of Rheumatology, Department of Internal Medicine, University Hospital, Geneva, Switzerland
3Department of Pathology and Immunology, University of Geneva School of Medicine, Geneva, Switzerland
Corresponding author: Cem Gabay, Cem.Gabay@hcuge.ch
Published: 28 July 2006 Arthritis Research Therapy 2006, 8:217 (doi:10.1186/ar2004)
This article is online at /content/8/5/217
© 2006 BioMed Central Ltd
Abstract long form of its receptor, Ob-Rb [7]. Both leptin-deficient
Leptin is produced primarily by adipocytes and functions in a (ob/ob) and leptin receptor (Ob-Rb)-deficient (db/db) mice
feedback loop regulating body weight. Leptin deficiency results in display a severe hereditary obesity phenotype, characterized
severe obesity and a variety of endocrine abnormalities in animals by increased food intake and body weight, associated with
and humans. Several studies indicated that leptin plays an important decreased energy expenditure [8]. Administration of leptin
role in immune responses. It exerts protective anti-inflammatory reverses the obese phenotype in ob/ob mice, but not in
effects in models of acute inflammation and during activation of
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